ArticleInternational journal of molecular sciences2026
Enzymatic/Mitochondrial Import Bottleneck in Sepsis with Possible Extensions to DIC: IV Glutathione and Hinokitiol as Potential Therapeutic Candidates.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Sepsis-induced disseminated intravascular coagulation (DIC) carries approximately 44% mortality and has no targeted mechanistic therapy. Stable isotope tracer data show whole-blood glutathione (GSH) synthesis falling by approximately 60% in sepsis despite paradoxically elevated cysteine flux, consistent with enzymatic failure at the glutamate-cysteine ligase (GCL) step rather than substrate shortage. We propose that GCL failure may unify endothelial coagulopathy and innate immune dysfunction in DIC, linked to the
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