ArticleInternational journal of molecular sciences2026
Radiosensitizing Effect of Gold Nanoparticles Stabilized with Sodium Citrate and Thioglycolic Acid on MDA-MB-231 and MCF7 Breast Cancer Cells.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Gold nanoparticles (AuNP) have been increasingly investigated as potential radiosensitizing agents for the treatment of cancer. In the present study, AuNP stabilized with sodium citrate and thioglycolic acid (AuNP-Cit-TGA) were synthesized to assess their radiosensitizing effects on MDA-MB-231 and MCF7 breast cancer cells after X-ray exposure. The AuNP-Cit-TGA displayed an average diameter of 22 nm, showcasing extremely low hemolytic activity in vitro, along with a moderate rate of cellular uptake. AuNP-Cit-TGA notably decreased cell viability in both cell lines 48 h after exposure to a radiation dose of 6 Gy, as demonstrated by the Alamar Blue assay. Dose-response clonogenic assay indicated a significant decrease in the survival of nanoparticle-treated MCF7 cells compared to control groups. This decrease was associated with heightened oxidative stress, as evidenced by increased DCFH fluorescence and a decrease in the expression of
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