Evidence map›Paper›PMID 42883874›Full record

SynthesisInternational journal of molecular sciences2026

Vaginal Microbial Risk Factors Associated with Human Papillomavirus-Induced Cervical Intraepithelial Neoplasia: A Systematic Review.

Ying Yi Chew, Aastha Sharma, Sheron Sir Loon Goh, Nafeesa Akma Mat Ali, Yolanda Augustin, Sanjeev Krishna, Ivy Chung, Milisha Koh A Magesvaran, Ayesha Masood, Cindy Shuan Ju Teh

Abstract readSystematic ReviewReview
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ying Yi ChewDepartment of Medical Microbiology, Universiti Malaya, Kuala Lumpur 50603, Malaysia.ORCID 0009-0005-9491-3875
Aastha SharmaDepartment of Medical Microbiology, Universiti Malaya, Kuala Lumpur 50603, Malaysia.
Sheron Sir Loon GohDepartment of Clinical Pharmacy and Pharmacy Practice, Universiti Malaya, Kuala Lumpur 50603, Malaysia.ORCID 0000-0003-3400-730X
Nafeesa Akma Mat AliSchool of Health and Medical Sciences, Institute of Infection and Immunity, City St George's University of London, London EC1V 0HB, UK.
Yolanda AugustinSchool of Health and Medical Sciences, Institute of Infection and Immunity, City St George's University of London, London EC1V 0HB, UK.
Sanjeev KrishnaSchool of Health and Medical Sciences, Institute of Infection and Immunity, City St George's University of London, London EC1V 0HB, UK.
Ivy ChungUniversiti Malaya Affordable Diagnostics and Therapeutics, Department of Pharmacology, Universiti Malaya, Kuala Lumpur 50603, Malaysia.
Milisha Koh A MagesvaranUniversiti Malaya Affordable Diagnostics and Therapeutics, Department of Pharmacology, Universiti Malaya, Kuala Lumpur 50603, Malaysia.
Ayesha MasoodDepartment of Public Health Sciences, Health Services Academy, Islamabad 44000, Pakistan.ORCID 0009-0007-5842-6206
Cindy Shuan Ju TehDepartment of Medical Microbiology, Universiti Malaya, Kuala Lumpur 50603, Malaysia.

Funding

Rafulin Holdings Sdn. Bhd. UM.000814/HPV.PV
6 · The paper itself

Abstract

Human papillomavirus (HPV) drives cervical carcinogenesis, but viral infection alone is insufficient for malignant transformation. The vaginal microbiome may modulate HPV persistence and cervical intraepithelial neoplasia (CIN) progression, yet existing reviews remain inconclusive. This systematic review identifies specific vaginal microbiome risk factors associated with HPV and CIN and proposes plausible mechanisms linking dysbiosis to disease progression. Following (PRISMA) guidelines, databases were searched for studies published through October 2025. Thirty-three studies from 2013 to 2025 across 10 countries met the inclusion criteria, with 87.9% exhibiting low risk of bias. Most studies demonstrated marked

Indexed as

Human Papillomavirus VirusesMicrobiotaPapillomavirus InfectionsUterine Cervical DysplasiaUterine Cervical NeoplasmsVaginaDysbiosisFemaleHumansLactobacillusPapillomaviridaeRisk Factorscervical intraepithelial neoplasiacommunity state typehuman papillomavirusvaginal microbiome

Identifiers

PMID42883874
PMCPMC13665079

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.