ArticleInternational journal of molecular sciences2026
Immunohistochemical Classification and Prognostic Significance of Germinal Center-like and Memory Cell-like Subtypes of Follicular Lymphoma Using FOXP1, LMO2, CD22, and MUM1.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Follicular lymphoma (FL) is an indolent B-cell lymphoma with considerable biological and clinical heterogeneity, highlighting the need for additional prognostic biomarkers beyond conventional clinicopathological parameters. This study aimed to evaluate the prognostic significance of an immunohistochemical classification separating FL into a germinal center-like (GC-like) phenotype, characterized by retention of germinal-center-associated features, and a memory-like (Mem-like) phenotype, reflecting a more differentiated post-germinal-center/memory B-cell state. Fifty-one patients with FL were retrospectively analyzed for clinicopathological characteristics, immunohistochemical findings, relapse, and overall survival (OS). LMO2 expression was detected in 70.6% of cases and was associated with lower mortality (19.4% vs. 60.0%,
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