ArticleInternational journal of molecular sciences2026
BMP-7 Enhances the Angiogenic Potential of Wharton's Jelly Mesenchymal Stem Cells Seeded in Decellularized Human Dental Pulp.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Regeneration of a pulp-dentin complex requires coordinated angiogenesis. This study investigated the angiogenic potential of Wharton's jelly mesenchymal stem cells (WJMSCs) in decellularized human dental pulp (DHDP) treated with bone morphogenetic protein-7 (BMP-7). Decellularized human dental pulp tissues were repopulated with WJMSCs, with or without BMP-7 (50 ng/mL). Degradation rate, swelling ratio, and pore size of DHDP samples were assessed. DHDP and repopulated DHDP were evaluated through hematoxylin and eosin and 4', 6-diamidino-2-phenylindole staining, and field-emission scanning electron microscopy. Biocompatibility of DHDP, BMP-7, and DHDP+BMP-7 on WJMSCs was assessed using the MTT assay. WJMSCs' viability was evaluated using a resazurin-based assay on days 7, 14, and 21. Angiogenic potential was assessed by measuring vascular endothelial growth factor-A (
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