Evidence map›Paper›PMID 42883844›Full record

ArticleInternational journal of molecular sciences2026

The Dual Nature of Sesamol: Tyrosinase-Dependent Bioactivation from an Inhibitor to a Cytotoxic Pro-Oxidant.

Hitomi Tanaka, Tomoko Nishimaki-Mogami, Shosuke Ito, Kazumasa Wakamatsu

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Hitomi TanakaDepartment of Medical Technology, School of Health Sciences, Gifu University of Medical Science, 795-1 Nagamine, Ichihiraga, Seki 501-3892, Gifu, Japan.ORCID 0000-0002-5646-9620
Tomoko Nishimaki-MogamiDivision of Biochemistry, National Institute of Health Sciences, Kawasaki-ku, Kawasaki 210-9501, Kanagawa, Japan.ORCID 0000-0003-0194-2377
Shosuke ItoInstitute for Melanin Chemistry, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake 470-1192, Aichi, Japan.ORCID 0000-0001-9182-5144
Kazumasa WakamatsuInstitute for Melanin Chemistry, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake 470-1192, Aichi, Japan.ORCID 0000-0003-1748-9001

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sesamol (3,4-methylenedioxyphenol) is a unique natural phenolic compound derived from sesame seeds that is characterized by its concurrent phenolic and methylenedioxy moieties. The purpose of this study was to investigate the tyrosinase-mediated metabolic activation of sesamol to determine whether a cytotoxic quinone intermediate is produced, mirroring the mechanism established for

Indexed as

BenzodioxolesEnzyme InhibitorsMonophenol MonooxygenaseOxidantsPhenolsAnimalsAntioxidantsCell Line, TumorGlutathioneHEK293 CellsHumansHydrogen PeroxideLevodopaMelaninsMiceOxidation-ReductionAntioxidantsBenzodioxolesEnzyme InhibitorsGlutathioneHydrogen PeroxideLevodopaMelaninsMonophenol MonooxygenaseOxidantsPhenolssesamolanti-agingcytotoxic effectsmelanin-producing cellspro-oxidant activityquinonesesamesesamol

Identifiers

PMID42883844
PMCPMC13665154

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.