ArticleInternational journal of molecular sciences2026
Regulation of Intestinal P-Glycoprotein by Gamma-Ray Irradiation: Impacts on Transporter Expression and Oxidative Stress.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
P-glycoprotein (P-gp), a key efflux drug transporter which plays a pivotal role in the in vivo pharmacokinetics of medications, undergoes alterations in expression and function following radiation exposure that can impact drug metabolism and therapeutic efficacy. Current research has found that clinical doses of radiation can affect the expression of drug transporters, while the underlying mechanisms associated with single high-dose irradiation remain to be thoroughly elucidated. This study investigates the effects of gamma-ray irradiation on the expression and transport activity of P-glycoprotein (P-gp) in various cell lines and murine small-intestinal tissues, and preliminarily explores the underlying regulatory mechanisms, thereby providing an experimental basis for research into drug transport abnormalities and interventions associated with radiation injury. Four different cell lines and male C57BL/6J mice were exposed to γ-ray irradiation from a
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