Impaired Brain Astrocytic Glycolysis in Neuropathic Pain: Insights from Transcriptomic Profiling to Metabolic Intervention.

Zhifeng Huang, Kailu Zou, Liqiong He, Malijiang Mulati, Qingwei Deng, Chunguang Yang, Changsheng Huang

Abstract read

In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Zhifeng HuangDepartment of Anesthesiology, Xiangya Hospital of Central South University, Changsha 410008, China.ORCID 0009-0002-5411-9771

Kailu ZouDepartment of Anesthesiology, Xiangya Hospital of Central South University, Changsha 410008, China.

Liqiong HeDepartment of Anesthesiology, Xiangya Hospital of Central South University, Changsha 410008, China.

Malijiang MulatiDepartment of Anesthesiology, Xiangya Hospital of Central South University, Changsha 410008, China.

Qingwei DengDepartment of Anesthesiology, Xiangya Hospital of Central South University, Changsha 410008, China.

Chunguang YangDepartment of Anesthesiology, Xiangya Hospital of Central South University, Changsha 410008, China.

Changsheng HuangDepartment of Anesthesiology, Xiangya Hospital of Central South University, Changsha 410008, China.

Funding

Health Research Project of the Hunan Provincial Health Commission 20256185National Natural Science Foundation of China 82501538National Natural Science Foundation of China 82571412

6 · The paper itself

Abstract

Neuropathic pain is a chronic disorder marked by sensory hypersensitivity and affective disturbances, yet current treatments often provide limited relief. Research on astrocytes in pain has focused largely on spinal mechanisms. Whether chronic peripheral nerve injury alters brain astrocytic metabolism remains unclear. Here, we isolated astrocytes from whole-brain preparations of adult mice after spared nerve injury (SNI) for transcriptomic profiling and identified coordinated suppression of astrocytic glycolysis, characterized by downregulation of genes (

Indexed as

AstrocytesBrainGlycolysisNeuralgiaAnimalsGene Expression ProfilingMaleMiceMice, Inbred C57BLTranscriptomeacetateastrocytesglycolytic deficitmetabolic reprogrammingneuropathic pain

Identifiers

PMID42883822

DOI10.3390/ijms27198575

PMCPMC13665073

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.