Evidence map›Paper›PMID 42883820›Full record

ArticleInternational journal of molecular sciences2026

Maternal Gestational Hypertension Is Associated with Reduced TSG-6 in Human Milk: Potential Implications for Neonatal Immunological Support.

Dominika Przywara, Adrianna Kondracka, Alicja Petniak, Patrycja Słyk-Gulewska, Magdalena Drąg, Urszula Szymanowska, Monika Czuba, Milena Jaremek, Aneta Strachecka, Janusz Kocki and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Dominika PrzywaraDepartment of Clinical Genetics, Medical University of Lublin, 11 Radziwillowska Str., 20-080 Lublin, Poland.ORCID 0000-0002-6143-9653
Adrianna KondrackaDepartment of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, 11 Staszica Str., 20-081 Lublin, Poland.
Alicja PetniakDepartment of Clinical Genetics, Medical University of Lublin, 11 Radziwillowska Str., 20-080 Lublin, Poland.ORCID 0000-0001-9926-0870
Patrycja Słyk-GulewskaDepartment of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, 11 Staszica Str., 20-081 Lublin, Poland.ORCID 0009-0008-6201-6514
Magdalena DrągDepartment of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, 11 Staszica Str., 20-081 Lublin, Poland.ORCID 0000-0002-9351-8997
Urszula SzymanowskaDepartment of Biochemistry and Food Chemistry, University of Life Sciences, 8 Skromna Str., 20-704 Lublin, Poland.ORCID 0000-0001-9692-2111
Monika CzubaDepartment of Clinical Genetics, Medical University of Lublin, 11 Radziwillowska Str., 20-080 Lublin, Poland.
Milena JaremekDepartment of Invertebrate Ecophysiology and Experimental Biology, Faculty of Environmental Biology, University of Life Sciences in Lublin, 54 Doświadczalna Street, 20-280 Lublin, Poland.ORCID 0000-0002-9504-2216
Aneta StracheckaDepartment of Invertebrate Ecophysiology and Experimental Biology, Faculty of Environmental Biology, University of Life Sciences in Lublin, 54 Doświadczalna Street, 20-280 Lublin, Poland.
Janusz KockiDepartment of Clinical Genetics, Medical University of Lublin, 11 Radziwillowska Str., 20-080 Lublin, Poland.ORCID 0000-0002-9541-6353
Paulina Gil-KulikDepartment of Clinical Genetics, Medical University of Lublin, 11 Radziwillowska Str., 20-080 Lublin, Poland.ORCID 0000-0003-3119-981X

Funding

Union of Lublin Universities Grant nr: INT/006/2025/IV-N).
6 · The paper itself

Abstract

Tumor necrosis factor alpha-stimulated protein 6 (TSG-6) is a potent anti-inflammatory mediator secreted by mesenchymal stem cells (MSCs). In human milk (HM), these cells (human milk mesenchymal stem cells, HM-MSCs) contribute to postnatal programming of the neonatal gastrointestinal immune axis. This study assessed how maternal gestational hypertension and maternal age affect the cytoprotective TSG-6 pool and its associated immunomodulatory microRNA signature in early milk. Early colostrum, 2-4 days postpartum, from healthy mothers and hypertensive patients was analyzed.

Indexed as

Cell Adhesion MoleculesHypertension, Pregnancy-InducedMilk, HumanAdultFemaleHumansInfant, NewbornMesenchymal Stem CellsMicroRNAsPregnancyCell Adhesion MoleculesMicroRNAsTNFAIP6 protein, humanfetal metabolic statusgestational hypertensionHM-MSCshuman milk mesenchymal stem cellsmicroRNATSG-6

Identifiers

PMID42883820
PMCPMC13665462

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.