Comparative RP-HPTLC Lipophilicity Analysis of Bioactive 1,3,4-Thiadiazole-Resorcinol Conjugates.

Beata Paw, Marek Studziński, Sylwia Stec, Katarzyna Barańska, Irena Malinowska, Joanna Matysiak

Abstract readComparative Study

In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Beata PawDepartment of Medicinal Chemistry, Medical University of Lublin, Jaczewskiego St. 4, 20-090 Lublin, Poland.

Marek StudzińskiDepartment of Physical Chemistry, Faculty of Chemistry, Institute of Chemical Sciences, Maria Curie-Skłodowska University, 20-031 Lublin, Poland.ORCID 0000-0001-8226-1922

Sylwia StecDepartment of Medicinal Chemistry, Medical University of Lublin, Jaczewskiego St. 4, 20-090 Lublin, Poland.

Katarzyna BarańskaIndependent Radiopharmacy Unit, Medical University of Lublin, Chodzki 4a, 20-093 Lublin, Poland.

Irena MalinowskaDepartment of Physical Chemistry, Faculty of Chemistry, Institute of Chemical Sciences, Maria Curie-Skłodowska University, 20-031 Lublin, Poland.

Joanna MatysiakDepartment of Chemistry, University of Life Sciences in Lublin, Akademicka 15, 20-950 Lublin, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The behavior of bioactive 1,3,4-thiadiazoles of anticancer potency and cholinesterases (ChEs) inhibitors was examined by high-performance thin-layer chromatography (HPTLC) in a reversed phase (RP) system. The chromatographic systems consisted of C-18 or C-8-bonded silica as the stationary phase and binary mixtures of water with methanol, acetonitrile, acetone, or dioxane as the mobile phase. The lipophilicity parameters R

Indexed as

Chromatography, Reverse-PhaseResorcinolsThiadiazolesChromatography, High Pressure LiquidChromatography, Thin LayerHydrophobic and Hydrophilic Interactions1,3,4-thiadiazoleresorcinolResorcinolsThiadiazoles1,3,4-thiadiazole-resorcinolscorrelation analysisHPTLClipophilicityorganic modifierRP-18RP-8

Identifiers

PMID42883808

DOI10.3390/ijms27198561

PMCPMC13665130

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