Evidence map›Paper›PMID 42883805›Full record

ReviewInternational journal of molecular sciences2026

Regulatory T Cells Across Oral Diseases: A Narrative Review on a Functional Perspective.

Yu Katsuma, Eiko Sakai, Yoshinori Sumita

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yu KatsumaDepartment of Medical Research and Development for Oral Disease, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8588, Japan.
Eiko SakaiDepartment of Medical Research and Development for Oral Disease, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8588, Japan.
Yoshinori SumitaDepartment of Medical Research and Development for Oral Disease, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8588, Japan.ORCID 0000-0002-1247-9763

Funding

Japan Society for the Promotion of Science 25K02816 (Y.S.), 26K12721 (E.S.)
6 · The paper itself

Abstract

Regulatory T cells (Tregs) maintain peripheral immune tolerance and are involved in various oral diseases with markedly different characteristics. In the oral field, Tregs have largely been discussed through reports on their distribution and numbers, and interpretations of whether their role is protective or pathogenic. Current identification markers do not directly assess the suppressive function, and reports on this function remain limited. This review focuses on the suppressive function of Tregs in the organization of oral diseases. Cells may express FOXP3 without exerting stable suppressive function, and the suppressive capacity of the same FOXP3

Indexed as

Mouth DiseasesT-Lymphocytes, RegulatoryAnimalsForkhead Transcription FactorsHumansForkhead Transcription FactorsFOXP3 protein, humanFOXP3immunosuppressive functionmedication-related osteonecrosis of the jaworal diseaseoral lichen planusoral squamous cell carcinomaperi-implantitisperiodontitisregulatory T cellsSjögren’s diseaseTh17/Treg balance

Identifiers

PMID42883805
PMCPMC13665054

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.