ReviewInternational journal of molecular sciences2026
A Mechanistic Framework for Somatic Mosaicism in Autoinflammatory Diseases Beyond Mendelian Inheritance.
Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
3 authors.
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Abstract
Hereditary autoinflammatory diseases have traditionally been defined as disorders caused by germline mutations in innate immune pathway genes transmitted through Mendelian inheritance, an assumption challenged by the discovery that postzygotic somatic mosaicism can reproduce similar autoinflammatory phenotypes. Aim of the review is to synthesize the mechanistic evidence for somatic and gonadal mosaicism across the major monogenic autoinflammatory diseases and to reassess the adequacy of "hereditary" as a categorical descriptor for this disease class. A structured narrative review of PubMed/MEDLINE was conducted (2002-2026), screening 241 records for evidence of somatic mosaicism in
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