Nonlinear Dose-Response Association Between Exercise Intensity and Urinary Liver-Type Fatty Acid-Binding Protein in Young Men: A Piecewise Threshold Analysis.

Hoa Do Thanh, Duan Duc Le, Tuan Nguyen Anh, Cuong Nguyen Thai, Ghi Nguyen Hai, Duong Le Xuan

Abstract readObservational Study

In one paragraph

Observational study in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hoa Do Thanh108 Military Central Hospital, No. 1 Tran Hung Dao Str., Hai Ba Trung Dist., Hanoi 100000, Vietnam.

Duan Duc Le108 Military Central Hospital, No. 1 Tran Hung Dao Str., Hai Ba Trung Dist., Hanoi 100000, Vietnam.ORCID 0009-0009-4813-5805

Tuan Nguyen Anh108 Military Central Hospital, No. 1 Tran Hung Dao Str., Hai Ba Trung Dist., Hanoi 100000, Vietnam.

Cuong Nguyen Thai108 Military Central Hospital, No. 1 Tran Hung Dao Str., Hai Ba Trung Dist., Hanoi 100000, Vietnam.

Ghi Nguyen Hai108 Military Central Hospital, No. 1 Tran Hung Dao Str., Hai Ba Trung Dist., Hanoi 100000, Vietnam.

Duong Le Xuan108 Military Central Hospital, No. 1 Tran Hung Dao Str., Hai Ba Trung Dist., Hanoi 100000, Vietnam.ORCID 0000-0002-8136-1320

Funding

108 Military Central Hospital 108 MCH

6 · The paper itself

Abstract

High-intensity physical exercise can induce temporary renal hemodynamic strain and subclinical tubular injury, yet the exact dose-response relationship remains poorly defined. This study investigated the relationship between exercise intensity and urinary liver-type fatty acid-binding protein (L-FABP) concentrations, a sensitive marker of proximal tubular stress, to identify an exploratory intensity threshold. We conducted an observational cohort study of 285 healthy young men undergoing a routine 20 min physical training session. Exercise intensity was quantified as metabolic equivalents of task (METs) using wearable accelerometers, and urinary L-FABP was measured pre-exercise and 30 min post-exercise. Post-exercise urinary L-FABP concentrations increased significantly from baseline (median, 1.89 vs. 0.90 µg/gCr;

Indexed as

ExerciseFatty Acid-Binding ProteinsAdultBiomarkersHumansMaleYoung AdultBiomarkersFatty Acid-Binding Proteinsacute kidney injuryexertional ischemiaproximal tubulesrenal hemodynamicsrenal tubular stresssegmented regression

Identifiers

PMID42883787

DOI10.3390/ijms27198539

PMCPMC13665119

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.