ReviewInternational journal of molecular sciences2026
Microbiome-Guided Maternal and Child Nutrition: A Structured Narrative Review of Indigenous African Foods, Fermented Foods, and Emerging Evidence.
Review in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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2 authors.
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Abstract
The gut microbiota is recognized as important to maternal and child health through associations with immune maturation, metabolic programming, barrier integrity, and early-life disease susceptibility. Indigenous food systems, fermented foods, probiotics, and postbiotics may influence gut microbial communities and functions, suggesting potential avenues for investigation into nutritional resilience, particularly in low-resource settings. This review synthesizes evidence on microbiome-informed maternal and child nutrition, focusing on indigenous foods, fermented foods, probiotics, postbiotics, and microbiome-mediated mechanisms. Literature was searched in PubMed, Scopus, Web of Science, ScienceDirect, and Google Scholar for studies, systematic reviews, and meta-analyses published between 2015 and 2025. Evidence indicates that microbiome-directed nutritional interventions may influence microbial metabolites, particularly short-chain fatty acids, and pathways associated with barrier integrity, immune regulation, and cellular signaling, including adenosine monophosphate-activated protein kinase (AMPK), mechanistic target of rapamycin (mTOR), mitogen-activated protein kinase (MAPK), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), toll-like receptor (TLR), and peroxisome proliferator-activated receptor (PPAR). Artificial intelligence, multi-omics, and precision nutrition may support the investigation and future development of more targeted approaches. However, gaps remain regarding population-specific microbiome profiles, standardized probiotic and postbiotic formulations, longitudinal maternal-infant relationships, and evidence from African and other low-resource settings. The Microbiome-Informed Nutrition Framework (MINF) is proposed as a hypothesis-generating model integrating indigenous food systems, microbiome-directed interventions, precision nutrition, and community-based primary healthcare as potential areas for future research, rather than established clinical or public health interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.