Observational studyInternational journal of molecular sciences2026
Purine Metabolism Profiling Reveals Distinct Associations of Uric Acid, Xanthine, and Hypoxanthine with Neurological Severity and Functional Outcome After Acute Ischemic Stroke.
Observational study in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purine metabolism and oxidative stress are increasingly recognized as important contributors to ischemic brain injury following acute ischemic stroke (AIS). Although uric acid has been extensively investigated because of its dual antioxidant and pro-oxidant properties, comparatively limited data exist regarding the prognostic relevance of upstream purine metabolites such as xanthine and hypoxanthine. The present study aimed to evaluate the association between serum uric acid, xanthine, and hypoxanthine concentrations and neurological severity and functional outcome following AIS. We performed a prospective observational cohort study including 143 consecutive patients admitted with acute ischemic stroke in a tertiary neurological center. Neurological severity was assessed using the National Institutes of Health Stroke Scale (NIHSS), while functional outcome was evaluated using the modified Rankin Scale (mRS) at discharge and at 3-month follow-up. Plasma xanthine and hypoxanthine concentrations were quantified using validated liquid chromatography-tandem mass spectrometry (LC-MS/MS) methodology. Distribution normality was assessed using Shapiro-Wilk and Kolmogorov-Smirnov testing. Comparative analyses were performed using Student's
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