Evidence map›Paper›PMID 42883731›Full record

ArticleInternational journal of molecular sciences2026

Chronic Cortisol Exposure Reshapes Chromatin Accessibility and Gene Expression: Implications for Growth and Welfare in Rainbow Trout (

Leonidas Larrondo, Cristian Reyes, Katalina Llanos-Azócar, Rodrigo Zuloaga, Daniela Aravena-Canales, Camila Godoy-Diaz, Alfredo Molina, Giorgia Daniela Ugarte, Juan Antonio Valdés

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Leonidas LarrondoLaboratorio de Biotecnología Molecular, Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago 8370186, Chile.
Cristian ReyesLaboratorio de Biotecnología Molecular, Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago 8370186, Chile.
Katalina Llanos-AzócarLaboratorio de Biotecnología Molecular, Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago 8370186, Chile.ORCID 0009-0002-5782-3721
Rodrigo ZuloagaLaboratorio de Biotecnología Molecular, Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago 8370186, Chile.ORCID 0000-0002-7820-7509
Daniela Aravena-CanalesLaboratorio de Biotecnología Molecular, Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago 8370186, Chile.ORCID 0000-0003-0196-9211
Camila Godoy-DiazLaboratorio de Biotecnología Molecular, Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago 8370186, Chile.ORCID 0009-0001-1978-0639
Alfredo MolinaLaboratorio de Biotecnología Molecular, Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago 8370186, Chile.ORCID 0000-0002-7411-5391
Giorgia Daniela UgarteLaboratorio de Biotecnología Molecular, Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago 8370186, Chile.
Juan Antonio ValdésLaboratorio de Biotecnología Molecular, Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago 8370186, Chile.ORCID 0000-0002-0615-820X

Funding

Agencia Nacional de Investigación y Desarrollo ANID INCAR2 CIA250009
6 · The paper itself

Abstract

Cortisol, the principal glucocorticoid in teleosts, coordinates the physiological response to stress by regulating metabolism, protein turnover, and growth. Although the molecular effects of acute cortisol exposure have been extensively characterized, the epigenomic mechanisms underlying skeletal muscle remodeling during prolonged cortisol elevation remain poorly understood. Here, we investigated how chronic cortisol reshapes chromatin accessibility and gene expression in rainbow trout (

Indexed as

ChromatinChromatin Assembly and DisassemblyGene Expression RegulationHydrocortisoneOncorhynchus mykissAnimalsFish ProteinsMuscle, SkeletalChromatinFish ProteinsHydrocortisoneATAC-seqchronic stresscortisolrainbow troutRNA-seqwelfare

Identifiers

PMID42883731
PMCPMC13664911

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.