ArticleInternational journal of molecular sciences2026
Gut Microbiome Signatures Associated with Osteoporotic Vertebral Compression Fracture.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Osteoporotic vertebral compression fracture (OVCF) is a clinically important condition associated with pain, disability, and impaired quality of life. Although osteoporosis is commonly diagnosed based on bone mineral density (BMD), fracture occurrence cannot be fully explained by BMD alone, suggesting that additional systemic factors may contribute to fracture susceptibility. The gut microbiome has recently emerged as a potential regulator of bone metabolism; however, its association with OVCF remains insufficiently characterized. In this study, fecal microbiome profiling using 16S rRNA gene sequencing was performed in 29 healthy controls, 11 patients with osteoporosis, and 25 patients with OVCF. Compared with the healthy control and osteoporosis groups, the OVCF group exhibited more distinct gut microbial compositional differences and reduced microbial diversity. Differential abundance analyses identified an increased relative abundance of
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