ArticleInternational journal of molecular sciences2026
Integrative Bioinformatics Across Proliferative and Non-Proliferative Cell States Reveals Novel Cytokinesis Genes.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The mammalian heart has no significant endogenous regenerative capacity, as mammalian cardiomyocytes undergo a last round of cell cycle after birth, becoming post-mitotic and polyploid. Consistent with this, cytokinesis inhibition in zebrafish impairs their cardiac regenerative capacity. Notably, re-induction of cell cycle progression or polyploidization reduction through cytokinesis generates proliferative mammalian cardiomyocytes. Thus, a better understanding of cytokinesis is fundamental. Here, we adopted an integrative bioinformatics approach to identify novel common candidate cytokinesis genes by comparing proliferative and non-proliferative cell states. The approach relies on (i) a temporal expression dataset profiling rat ventricles during heart development, (ii) a transcriptomics dataset profiling postnatal rat cardiomyocytes upon stimulation with pro-proliferative compounds, and (iii) an expression dataset profiling mouse embryonic fibroblasts upon knockout of Lin9, a master regulator of cell division. Following prioritization of the identified 236 novel candidate cytokinesis genes and literature-based investigations,
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