ArticleInternational journal of molecular sciences2026
pTINCR Expression Is Associated with Tumor Aggressiveness but Does Not Independently Predict Prognosis in Head and Neck Cutaneous Squamous Cell Carcinoma.
Article in International journal of molecular sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Terminal differentiation-induced non-coding RNA (TINCR), initially classified as a long non-coding RNA, encodes a biologically active microprotein (pTINCR) involved in epidermal differentiation and tumor biology. However, the clinicopathological and prognostic relevance of pTINCR expression in cutaneous squamous cell carcinoma (cSCC) remains unclear. We conducted a retrospective case-control study including 116 patients with head and neck cSCC: 58 patients who developed nodal metastasis and 58 non-metastatic controls. pTINCR expression was assessed by immunohistochemistry and analyzed in relation to clinicopathological characteristics and clinical outcomes. Unconditional logistic regression was used to evaluate its association with nodal metastasis. Cox proportional hazards models were additionally used to explore associations with time-to-event outcomes. Negative pTINCR expression was significantly associated with tumor thickness > 6 mm (
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