Mulberry Polyphenols Ameliorate Metabolic Abnormalities Accompanied by Spatial Microbial and Short-Chain Fatty Acid Alterations in Type 2 Diabetic Mice.

Tong Zhang, Ping-Ping Wang, Abdulla Yusuf, Fu Xiong, Chun Chen

Abstract read

In one paragraph

Article in Foods (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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5 authors.

Tong ZhangThe Key Laboratory of Xinjiang Native Medicinal and Edible Plant Resources Chemistry, College of Chemistry and Environmental Science, Kashi University, Kashi 844000, China.

Ping-Ping WangSchool of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China.

Abdulla YusufThe Key Laboratory of Xinjiang Native Medicinal and Edible Plant Resources Chemistry, College of Chemistry and Environmental Science, Kashi University, Kashi 844000, China.ORCID 0000-0002-0685-2381

Fu XiongSchool of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China.

Chun ChenThe Key Laboratory of Xinjiang Native Medicinal and Edible Plant Resources Chemistry, College of Chemistry and Environmental Science, Kashi University, Kashi 844000, China.ORCID 0000-0002-2178-1438

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gut microbiota may contribute to the anti-diabetic effects of mulberry polyphenols (MPs), although the associated spatial microbial patterns and metabolic alterations remain unclear. We investigated microbiota composition in fecal, cecal, and colonic samples and temporal changes in fecal short-chain fatty acids (SCFAs) during an 8-week MP intervention in type 2 diabetic (T2DM) mice using 16S rRNA sequencing and gas chromatography. MPs effectively reduced fasting blood glucose and improved diabetes-associated pathological alterations. Spatially, MP administration was associated with distinct changes in the ascending colonic microecology, characterized by an increased relative abundance of

Indexed as

gut microbiotamulberry polyphenolsshort-chain fatty acidsspatiotemporal heterogeneitytype 2 diabetes mellitus

Identifiers

PMID42883674

DOI10.3390/foods15193568

PMCPMC13665092

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.