ArticleFoods (Basel, Switzerland)2026
Depolymerized Fucoidan Alleviates High-Fat Diet-Induced Obesity in Association with Alterations in Gut Microbiota and Metabolic Profiles.
Xiaona Sun, Lin Bai, Changyu Su, Chunqing Ai, Xiaomeng Ren, Fanhua Kong, Shuang Song
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In one paragraphArticle in Foods (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
Xiaona SunSchool of Smart New Agricultural Industry, Dalian Art College, Dalian 116600, China.
Lin BaiSKL of Marine Food Processing & Safety Control, National Engineering Research Center of Seafood, Collaborative Innovation Center of Seafood Deep Processing, National & Local Joint Engineering Laboratory for Marine Bioactive Polysaccharide Development and Application, Liaoning Key Laboratory of Food Nutrition and Health, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China.
Changyu SuSKL of Marine Food Processing & Safety Control, National Engineering Research Center of Seafood, Collaborative Innovation Center of Seafood Deep Processing, National & Local Joint Engineering Laboratory for Marine Bioactive Polysaccharide Development and Application, Liaoning Key Laboratory of Food Nutrition and Health, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China.
Chunqing AiSKL of Marine Food Processing & Safety Control, National Engineering Research Center of Seafood, Collaborative Innovation Center of Seafood Deep Processing, National & Local Joint Engineering Laboratory for Marine Bioactive Polysaccharide Development and Application, Liaoning Key Laboratory of Food Nutrition and Health, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China.ORCID 0000-0003-2172-3198 Xiaomeng RenSKL of Marine Food Processing & Safety Control, National Engineering Research Center of Seafood, Collaborative Innovation Center of Seafood Deep Processing, National & Local Joint Engineering Laboratory for Marine Bioactive Polysaccharide Development and Application, Liaoning Key Laboratory of Food Nutrition and Health, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China.ORCID 0000-0002-0698-4878 Fanhua KongSKL of Marine Food Processing & Safety Control, National Engineering Research Center of Seafood, Collaborative Innovation Center of Seafood Deep Processing, National & Local Joint Engineering Laboratory for Marine Bioactive Polysaccharide Development and Application, Liaoning Key Laboratory of Food Nutrition and Health, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China.
Shuang SongSKL of Marine Food Processing & Safety Control, National Engineering Research Center of Seafood, Collaborative Innovation Center of Seafood Deep Processing, National & Local Joint Engineering Laboratory for Marine Bioactive Polysaccharide Development and Application, Liaoning Key Laboratory of Food Nutrition and Health, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China.ORCID 0000-0001-9718-8254 Funding
Dalian Art College 7010800700220National Natural Science Foundation of China U24A20470
6 · The paper itselfAbstract
Obesity is a major global health concern associated with various metabolic disorders. Fucoidan, a seaweed-derived sulfated polysaccharide, has shown potential in alleviating obesity through modulation of gut microbiota. However, comparative effects of native and depolymerized fucoidan (Dfuc) on HFD-induced obesity and gut microbiota dysbiosis remain unclear. In this study, we compared the anti-obesity effects of fucoidan and Dfuc and evaluated their regulatory effects on gut microbiota and microbial metabolites in HFD-fed mice. Results showed that fucoidan and Dfuc reduced body weight gain, fat accumulation and hepatic lipid abnormalities. They also alleviated liver injury and oxidative stress and inflammation in hepatic and colonic tissues, with Dfuc significantly improving parameters such as serum AST, hepatic MDA, SOD activity, and TNF-α expression compared to the HF group. Furthermore, gut microbiota analysis showed that both fucoidan and Dfuc treatments enriched
Indexed as
gut microbiotametabolitesobesityseaweed polysaccharides
Identifiers
PMID42883615
PMCPMC13665278
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