ArticleBiology2026
Endpoint-Dependent Biochemical and Histopathological Effects of Orientin in a Short-Term 3-Nitropropionic Acid Mouse Model.
Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
12 authors.
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Abstract
objectiveThe objective of this study was to describe the biochemical and histopathological changes associated with orientin co-administration in a short-term 3-nitropropionic acid (3-NPA) mouse model.
methodsTwenty-four adult female Swiss albino mice were allocated to Control, Orientin, 3-NPA, and 3-NPA + Orientin groups (
resultsFactorial analysis identified endpoint-dependent 3-NPA and orientin effects. Relative to 3-NPA alone, co-treatment increased GSH, SOD, and CAT and reduced MDA, caspase-3, and MCP-1. GPx, COX-2, and iNOS did not differ significantly between the 3-NPA and combined-treatment groups. Histopathological injury appeared less extensive with co-treatment. Although 8-OHdG and 4-HNE staining was lower descriptively, the pairwise IRS comparisons between the 3-NPA and combined-treatment groups were not significant; GFAP did not differ among groups.
conclusionOrientin co-administration was associated with a partial, endpoint-dependent biochemical and histopathological profile. Because behavioral outcomes and direct pathway or target-intervention experiments were not performed, these findings do not establish functional neuroprotection or a specific molecular mechanism.
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