Evidence map›Paper›PMID 42883444›Full record

ReviewBiology2026

Update in the Molecular Pathogenesis of Sebaceous Carcinoma.

Francisco Mano, João Teixeira, José Carlos Cardoso

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Francisco ManoDepartment of Dermatology and Venereology, Coimbra University Hospital, Coimbra Local Health Unit, Praceta Professor Mota Pinto, Celas, 3004-561 Coimbra, Portugal.
João TeixeiraDepartment of Dermatology and Venereology, Coimbra University Hospital, Coimbra Local Health Unit, Praceta Professor Mota Pinto, Celas, 3004-561 Coimbra, Portugal.ORCID 0000-0003-4157-4652
José Carlos CardosoDepartment of Dermatology and Venereology, Coimbra University Hospital, Coimbra Local Health Unit, Praceta Professor Mota Pinto, Celas, 3004-561 Coimbra, Portugal.ORCID 0000-0001-7113-7061

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sebaceous carcinoma is an uncommon but potentially aggressive adnexal malignancy whose molecular pathogenesis has been substantially clarified in recent years. Rather than representing a single molecular entity, sebaceous carcinoma is now understood as a biologically heterogeneous group of tumors arising through distinct yet sometimes overlapping oncogenic pathways. Recent genomic and multi-omics studies have identified several major molecular subsets, including mismatch repair-deficient (dMMR)/microsatellite instability (MSI)-associated tumors, ultraviolet (UV) radiation-driven tumors, and pauci-mutational tumors characterized predominantly by alterations in cell-cycle and epithelial differentiation regulators such as

Indexed as

extraocular sebaceous carcinomaimmunotherapyLynch syndromemicrosatellite instabilitymismatch repair deficiencyMuir–Torre syndromeNOTCH1ocular sebaceous carcinomaRB1sebaceous carcinomaTP53tumor mutational burdenZNF750

Identifiers

PMID42883444
PMCPMC13664352

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.