Effects of Chronic Paroxetine Exposure and Irisin Treatment on Sexual Motivation, Reproductive Endocrine Profile, and Vaginal Histological and Immune-Inflammatory Outcomes in Adult Female Rats.

Ahmet Yardimci, Tugrul Ertugrul, Nazife Ulker Ertugrul, Sinan Canpolat

Abstract read

In one paragraph

Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ahmet YardimciDepartment of Physiology, Faculty of Medicine, Firat University, 23119 Elazig, Turkey.ORCID 0000-0001-5740-9518

Tugrul ErtugrulDepartment of Histology and Embryology, Faculty of Veterinary Medicine, Ondokuz Mayis University, 55200 Samsun, Turkey.

Nazife Ulker ErtugrulDepartment of Physiology, Faculty of Medicine, Samsun University, 55080 Samsun, Turkey.ORCID 0000-0002-3805-2362

Sinan CanpolatDepartment of Physiology, Faculty of Medicine, Dokuz Eylul University, 35220 Izmir, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Selective serotonin reuptake inhibitors (SSRIs), particularly paroxetine, are frequently associated with sexual dysfunction, yet their effects on female reproductive endocrine regulation and the local vaginal tissue environment remain incompletely characterized. Irisin is an exercise-responsive adipomyokine with reported reproductive and immunomodulatory actions, but its influence during chronic paroxetine exposure is unknown. This study evaluated the behavioral, endocrine, histological, and immune-related effects of chronic paroxetine treatment and examined whether irisin changed responses. Forty regularly cycling female Sprague-Dawley rats were allocated to sham control, paroxetine, irisin, or paroxetine + irisin groups (

Indexed as

active investigation behaviorsfibroblastirisinnuclear factor-kappa Bparoxetineplasma cellselective serotonin reuptake inhibitorssexual motivationtoll-like receptor 4

Identifiers

PMID42883440

DOI10.3390/biology15191767

PMCPMC13664256

What OpenQuestion holds

Textmetadata

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.