Evidence map›Paper›PMID 42883388›Full record

ArticleBiology2026

Andrographolide Promotes Post-Ischemic Endothelial Angiogenic Activity via IL-10-Mediated M2-Like Microglia-Endothelial Crosstalk Involving Endothelial VEGFR2 Upregulation.

Hongfei Li, Hairong Xiang, Xinyu Li, Jiazhen Xie, Linfeng Zhao, Lan Yang, Riyi Shi, Yong Wang, Liangqin Shi

Abstract read
In one paragraph

Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hongfei LiCollege of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Hairong XiangCollege of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Xinyu LiSchool of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Jiazhen XieCollege of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Linfeng ZhaoCollege of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Lan YangCollege of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Riyi ShiCenter for Paralysis Research, Department of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA.
Yong WangCollege of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.ORCID 0000-0001-6602-0491
Liangqin ShiCollege of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.

Funding

Chengdu University of Traditional Chinese Medicine CCCXFH202205China Postdoctoral Science Foundation 2023M742508National Natural Science Foundation of China 82304917Sichuan Provincial Academy of Natural Resource Sciences 2025ZNSFSC1651
6 · The paper itself

Abstract

Ischemic stroke remains a leading cause of disability worldwide, and angiogenesis is critical for functional recovery. Although andrographolide (ANP) has anti-inflammatory and neuroprotective properties, its role in post-stroke angiogenesis remains unclear. Here, we investigated whether ANP promotes post-ischemic angiogenesis by modulating microglia-endothelial crosstalk. Using a ferric chloride (FeCl

Indexed as

Androprapholideangiogenic activityIL-10ischemic strokeM2-like microgliaVEGFR2

Identifiers

PMID42883388
PMCPMC13663447

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.