Corncob-Derived Xylo-Oligosaccharides Attenuate Acrylamide-Induced Gut-Liver Toxicity in Mice, Associated with Modulation of Gut Microbiota and SCFA Metabolism.

Le He, Yanjuan Chen, Ruiping Luo, Zhongke Sun, Erting Liu, Lili Li, Zonghao Yue

Abstract read

In one paragraph

Article in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Le HeSchool of Life Sciences and Agronomy, Zhoukou Normal University, Zhoukou 466001, China.

Yanjuan ChenSchool of Mechanical and Electrical Engineering, Zhoukou Normal University, Zhoukou 466001, China.

Ruiping LuoSchool of Life Sciences and Agronomy, Zhoukou Normal University, Zhoukou 466001, China.

Zhongke SunSchool of Biological Engineering, Henan University of Technology, Zhengzhou 450001, China.

Erting LiuHenan Heagreen Bio-Technology Co., Ltd., Zhoukou 466001, China.

Lili LiSchool of Life Sciences and Agronomy, Zhoukou Normal University, Zhoukou 466001, China.

Zonghao YueSchool of Life Sciences and Agronomy, Zhoukou Normal University, Zhoukou 466001, China.ORCID 0000-0002-3797-1455

Funding

Henan Science and Technology Department 252102320258Scientific Research Foundation for High-level Talents of Zhoukou Normal University 72063

6 · The paper itself

Abstract

Acrylamide (AA) is a common foodborne toxicant formed during the thermal processing of starch-rich foods and poses significant risks to the gut-liver axis. Although corncob-derived xylo-oligosaccharides (XOS) have emerged as promising prebiotics with multiple bioactivities, their protective effects against foodborne toxicants have not been explored. This study investigated the ameliorative effects of dietary corncob-derived XOS on AA-induced gut-liver toxicity and the underlying mechanisms in mice. Female C57BL/6J mice were gavaged with AA and concurrently fed diets with or without 7.0% XOS for 7 weeks. The results showed that XOS effectively alleviated AA-induced gut-liver toxicity, as evidenced by attenuated intestinal and hepatic inflammation (decreased pro-inflammatory cytokines IL-6 in colon, TNF-α, and IL1-β in liver; increased anti-inflammatory IL-10 in colon and liver), restored intestinal barrier integrity (upregulated

Indexed as

acrylamidegut–liver toxicitygut microbiotamiceshort chain fatty acidxylo-oligosaccharides

Identifiers

PMID42883357

DOI10.3390/biology15191684

PMCPMC13663374

What OpenQuestion holds

Textmetadata

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.