Evidence map›Paper›PMID 42883351›Full record

ReviewBiology2026

N6-Methyladenosine and 5-Methylcytosine Epitranscriptomic Regulation of Male Reproduction and Fertility.

Sana M Salih, Ayman Al-Hendy, Qiwei Yang

Abstract readReview
In one paragraph

Review in Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sana M SalihReproductive Endocrinology and Infertility Section, Department of Obstetrics and Gynecology, University of Chicago, Chicago, IL 60637, USA.
Ayman Al-HendyDepartment of Obstetrics and Gynecology, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0002-8778-4447
Qiwei YangDepartment of Obstetrics and Gynecology, University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0001-7131-8946

Funding

VIRAL ONCOLOGY CORE FACILITYP30CA014599 · NCI · UNIVERSITY OF CHICAGO · PI MARK W. LINGEN · 1985 to 2026
$122.1M
Pathological reprogramming of the m6A epitranscriptome in uterine fibroidsR01HD106285 · NICHD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI AL-HENDY, AYMAN, BOYER, THOMAS G · 2021 to 2025
$3.2M
Decoding the pseudouridine epitranscriptome in uterine fibroids.R01HD124930 · NICHD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI THOMAS G BOYER, QIWEI YANG · 2026 to 2026
$699k
NCI NIH HHS P30 CA014599NCI NIH HHS P30CA014599NICHD NIH HHS R01 HD106285NICHD NIH HHS R01 HD124930NIH HHS 1R01HD106285-26NIH HHS HD124930
6 · The paper itself

Abstract

Functional spermatozoa production depends on spermatogenesis, a complex developmental process that requires precise regulation of gene expression at multiple levels. Although considerable progress has been made in understanding the transcriptional and epigenetic mechanisms governing germ cell development, post-transcriptional regulation mediated by RNA modifications has recently emerged as an important component of male fertility regulation. Epitranscriptomics, the study of chemical RNA modifications and their associated regulatory proteins, has revealed diverse roles for RNA modifications in spermatogenesis, sperm maturation, fertilization, and early embryonic development. Among more than 170 RNA modifications identified to date, N

Indexed as

epitranscriptomicsfertility biomarkersgerm cellsm5Cm6Amale infertilityreproductive epigeneticsRNA modificationsspermatogenesissperm function

Identifiers

PMID42883351
PMCPMC13663535

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.