Evidence map›Paper›PMID 42883332›Full record

ArticleMolecules (Basel, Switzerland)2026

Design and Synthesis of New Thiazole Derivatives for Alzheimer's Disease Therapy as a Potential Cholinesterase Inhibitor; Toxicity Prediction and Molecular Docking Studies and Biological Evaluation.

Mesut Işık, Gresa Halimi Syla, Abdüllatif Karakaya, Ulviye Acar Çevik, Nour El-Huda Daoud, Muhammet Fırat, Yüksel Öğünç Keçeci, Yusuf Özkay, Zafer Asım Kaplancıklı, Şükrü Beydemir

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mesut IşıkDepartment of Bioengineering, Faculty of Engineering, Bilecik Şeyh Edebali University, 11230 Bilecik, Turkey.ORCID 0000-0002-4677-8104
Gresa Halimi SylaFaculty of Pharmacy, University for Business and Technology, 60000 Prishtina, Kosovo.ORCID 0000-0002-0635-0664
Abdüllatif KarakayaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Zonguldak Bulent Ecevit University, 67600 Zonguldak, Turkey.
Ulviye Acar ÇevikDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey.
Nour El-Huda DaoudDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman 19328, Jordan.
Muhammet FıratDepartment of Biotechnology, Graduate Education Institute, Bilecik Seyh Edebali University, 11230 Bilecik, Turkey.
Yüksel Öğünç KeçeciDepartment of Biochemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskisehir, Turkey.
Yusuf ÖzkayDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey.ORCID 0000-0001-8815-153X
Zafer Asım KaplancıklıDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey.ORCID 0000-0003-2252-0923
Şükrü BeydemirDepartment of Biochemistry, Faculty of Pharmacy, Anadolu University, 26470 Eskisehir, Turkey.

Funding

Anadolu University
6 · The paper itself

Abstract

In this study, thiazole derivatives

Indexed as

Alzheimer DiseaseCholinesterase InhibitorsDrug DesignThiazolesAcetylcholinesteraseAnimalsButyrylcholinesteraseHumansMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipAcetylcholinesteraseButyrylcholinesteraseCholinesterase InhibitorsThiazolesAlzheimer’s diseasecholinesterase inhibitionmolecular dockingthiazole

Identifiers

PMID42883332
PMCPMC13666930

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.