Production and Characterization of β-Cyclodextrin Inclusion Complexes Containing Conjugated Linoleic Acid from Njangsa (

Anh T L Nguyen, Cecile T Ojong, Pierre Dutilleul, Alberta N A Aryee

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Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 authors.

Anh T L NguyenFood Science and Biotechnology Program, Department Human Ecology, College of Agriculture, Science and Technology, Delaware State University, 1200 N DuPont Highway, Dover, DE 19901, USA.

Cecile T OjongFood Science and Biotechnology Program, Department Human Ecology, College of Agriculture, Science and Technology, Delaware State University, 1200 N DuPont Highway, Dover, DE 19901, USA.

Pierre DutilleulDepartment of Plant Science, Agricultural and Environmental Sciences, McGill University, 21111 Lakeshore Road, Sainte-Anne-de-Bellevue, QC H9X 3V9, Canada.ORCID 0000-0002-2381-3421

Alberta N A AryeeFood Science and Biotechnology Program, Department Human Ecology, College of Agriculture, Science and Technology, Delaware State University, 1200 N DuPont Highway, Dover, DE 19901, USA.ORCID 0000-0002-1874-9066

Funding

National Institute of Food and Agriculture DELXANAA082018USDA-NIFA CBG 2024-38821-42103

6 · The paper itself

Abstract

Njangsa seed oil (NSO) is rich in polyunsaturated fatty acids and represents an underexplored plant source for producing conjugated linoleic acid (CLA). This study explored the production of CLA from NSO via alkali isomerization, as well as and its stabilization by β-cyclodextrin (β-CD) inclusion complexation. A 3-factor factorial design was used to optimize reaction conditions, yielding a maximum purified CLA content of 46.42% from 2.5 g NSO at 180 °C for 3 h, with cis-9, trans-11 CLA as the predominant isomer. Inclusion complexation produced microparticles averaging 19.73 µm with 83.36% inclusion efficiency. Complexed CLA showed lower peroxide, para-anisidine, and thiobarbituric acid values than free CLA, indicating improved oxidative stability. Fourier transform infrared spectroscopy showed spectral changes consistent with interactions between the CLA-rich fraction and β-CD, while scanning electron microscopy and X-ray diffraction revealed changes in morphology and crystalline organization, respectively. These findings demonstrate the feasibility of producing NSO-enriched CLA and enhancing its oxidative stability through β-CD inclusion complexation.

Indexed as

alkali isomerizationcomplexationconjugated linoleic acidoxidative stabilityβ-cyclodextrin

Identifiers

PMID42883324

DOI10.3390/molecules31193560

PMCPMC13666739

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.