ArticleMolecules (Basel, Switzerland)2026
Synthesis, Biological Evaluation, and Molecular Docking of Pyridine-Containing Squaramides as DNase I Inhibitors.
Mariyana Atanasova, Nina Ruseva, Georgi Tirolski, Simeon Stoyanov, Ana Marković, Andrija Šmelcerović, Magdalena Angelova, Hristina Sbirkova-Dimitrova, Adriana Bakalova, Rositsa Mihaylova and 1 more
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In one paragraphArticle in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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11 authors.
Mariyana AtanasovaDepartment of Chemistry, Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Str., 1000 Sofia, Bulgaria.ORCID 0000-0001-9761-0355 Nina RusevaDepartment of General and Inorganic Chemistry, University of Chemical Technology and Metallurgy, 1756 Sofia, Bulgaria.
Georgi TirolskiInstitute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. G. Bontchev Str., Bl. 9, 1113 Sofia, Bulgaria.
Simeon StoyanovInstitute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. G. Bontchev Str., Bl. 9, 1113 Sofia, Bulgaria.
Ana MarkovićDepartment of Pharmacy, Faculty of Medicine, University of Niš, Blvd. Dr Zorana Đinđića 81, 18000 Niš, Serbia.
Andrija ŠmelcerovićDepartment of Chemistry, Faculty of Medicine, University of Niš, Blvd. Dr Zorana Đinđića 81, 18000 Niš, Serbia.ORCID 0000-0001-7724-0967 Magdalena AngelovaInstitute of Mineralogy and Crystallography, "Akad. Ivan Kostov", Bulgarian Academy of Sciences, Acad. Georgi Bonchev Str., Bl. 107, 1113 Sofia, Bulgaria.
Hristina Sbirkova-DimitrovaInstitute of Mineralogy and Crystallography, "Akad. Ivan Kostov", Bulgarian Academy of Sciences, Acad. Georgi Bonchev Str., Bl. 107, 1113 Sofia, Bulgaria.
Adriana BakalovaDepartment of Chemistry, Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Str., 1000 Sofia, Bulgaria.ORCID 0000-0002-3017-3258 Rositsa MihaylovaCentre of Excellence in Informatics and Information and Communication Technologies, Bulgarian Academy of Sciences, Akad. Georgi Bonchev Str., Block 2 and 25A, 1113 Sofia, Bulgaria.ORCID 0000-0001-5763-0730 Emiliya ChernevaDepartment of Chemistry, Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Str., 1000 Sofia, Bulgaria.ORCID 0000-0002-1097-1850 Funding
Bulgarian Science Fund KP06-Kitai/6European Union BG16RFPR002-1.014-0007Ministry of Science, Technological Development, and Innovation 451-03-137/2025-03/200113
6 · The paper itselfAbstract
backgroundDNase I inhibitors may be useful as biochemical tools and as potential leads for investigating pathological processes associated with excessive DNA degradation. Squaramides represent attractive scaffolds for drug discovery owing to their rigid, highly polarized structure and versatile hydrogen-bonding properties.
methodsFour novel pyridine-containing squaramides (
resultsAll compounds inhibited bovine pancreatic DNase I, with IC
conclusionsPyridine-containing squaramides represent a promising scaffold for further investigation as DNase I inhibitors, with
Indexed as
CyclobutanesDeoxyribonuclease IEnzyme InhibitorsMolecular Docking SimulationPyridinesQuinolinesAnimalsCattleCell Line, TumorHumansMolecular StructureQuinineStructure-Activity RelationshipCyclobutanesDeoxyribonuclease IEnzyme InhibitorspyridinePyridinesQuinineQuinolinessquaramideDNase I inhibitorsenzyme inhibitionmolecular dockingpyridine-containing compoundssquaramides
Identifiers
PMID42883314
PMCPMC13667282
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