Determination of the Content of Isoquinoline Alkaloids in Selected Plant Extracts and Study of Their Cholinesterase-Inhibiting Activity and Cytotoxicity Against Human Melanoma Cells Using In Vitro and In Silico Methods.

Tomasz Tuzimski, Anna Petruczynik, Mateusz Sugajski, Tomasz Plech, Barbara Kaproń-Plech, Karol Wróblewski, Bogusław Buszewski

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Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Tomasz TuzimskiDepartment of Physical Chemistry, Medical University of Lublin, Chodzki 4a, 20-093 Lublin, Poland.ORCID 0000-0003-3729-3196

Anna PetruczynikDepartment of Inorganic Chemistry, Medical University of Lublin, Chodzki 4a, 20-093 Lublin, Poland.ORCID 0000-0003-3294-3217

Mateusz SugajskiDepartment of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University in Torun, Gagarina 7, 87-100 Torun, Poland.ORCID 0000-0001-6451-3436

Tomasz PlechDepartment of Pharmacology, Faculty of Health Sciences, Medical University of Lublin, Radziwiłłowska 11, 20-080 Lublin, Poland.

Barbara Kaproń-PlechDepartment of Clinical Genetics, Faculty of Medicine, Medical University of Radziwiłłowska, 20-080 Lublin, Poland.

Karol WróblewskiLaboratory of Commercial and Non-Commercial Clinical Trials, University of Rzeszów, Kopisto 2a, 35-959 Rzeszów, Poland.ORCID 0000-0002-8918-7056

Bogusław BuszewskiKuyavian-Pomeranian Science and Technology Center of prof. Jan Czochralski, Krasińskiego 4/4A, 87-100 Torun, Poland.ORCID 0000-0002-5482-7500

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Different plants containing isoquinoline alkaloids are known to exhibit various biological activities such as anti-inflammatory, antimicrobial, antiviral, antioxidant, antihyperglycemic, cholesterol-lowering, antifungal and anticancer behaviors. Diseases that pose a significant health burden include neurodegenerative diseases and cancer. Current treatments for these diseases are still inadequate, so new therapeutic agents are needed to treat them more effectively. The aim of this study was to determine the content of selected isoquinoline alkaloids in plant extracts obtained from the leaves of

Indexed as

AlkaloidsAntineoplastic Agents, PhytogenicCholinesterase InhibitorsIsoquinolinesMelanomaPlant ExtractsAcetylcholinesteraseButyrylcholinesteraseCell Line, TumorHumansMenispermaceaeMolecular Docking SimulationAcetylcholinesteraseAlkaloidsAntineoplastic Agents, PhytogenicButyrylcholinesteraseCholinesterase InhibitorsisoquinolineIsoquinolinesPlant Extractsacetylcholinesteraseanticancer activitybutyrylcholinesteraseisoquinoline alkaloidsliquid chromatographyplant extracts

Identifiers

PMID42883309

DOI10.3390/molecules31193544

PMCPMC13666729

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.