ArticleMolecules (Basel, Switzerland)2026
A Dual-Functional Magnetic Nanoparticle for Rapid Extraction and Targeted Tumor Delivery of Tiancimycin.
Chengyu Zhang, Peng Zhong, Daxin Zhao, Yun Lv, Ximeng Zhang, Chunyan Chen, Huijuan Yu, Xin Chai, Yunsha Zhang, Jiaxing Zhang and 2 more
Abstract read
In one paragraphArticle in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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5 · Who and what moneyAuthors and funding
12 authors.
Chengyu ZhangNational Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Peng ZhongNational Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Daxin ZhaoNational Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Yun LvNational Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Ximeng ZhangNational Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Chunyan ChenNational Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Huijuan YuNational Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.ORCID 0000-0003-3222-7608 Xin ChaiNational Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Yunsha ZhangSchool of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Jiaxing ZhangChemical Engineering Research Center, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.ORCID 0000-0003-4104-6657 Yuefei WangNational Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
Xiaohui YanNational Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.ORCID 0000-0001-7295-8902 Funding
Science and Technology Project of Haihe Laboratory of Modern Chinese Medicine 25HHZYSS00024the Special Project for Technological Innovation in New Productive Forces of Modern Chinese Medicines 24ZXZKSY00010the State Key Laboratory of Chinese Medicine Modernization CBCM2025207Tianjin Education Commission Research Program Project 2023KJ146
6 · The paper itselfAbstract
Anthraquinone-fused enediynes (AFEs) are a class of microbial natural products with remarkable cytotoxicity and exhibit promising application prospects in tumor therapy. Taking tiancimycins (TNMs) as an example, this class of compounds holds great potential against triple-negative breast and liver cancers. However, the low production titers of AFEs in actinobacterial hosts make their enrichment and separation processes both cumbersome and costly. Therefore, the main objective of this study was to develop a rapid and reusable magnetic platform for TNM enrichment and recovery. Inspired by the pi-pi stacking interactions between AFEs and their natural binding proteins in the producing strains, this study designed and prepared alizarin- and folic acid-co-modified magnetic nanoparticles (PNMP-AZ-FA). On the one hand, these nanoparticles can directly and specifically adsorb TNMs from the crude extract of
Indexed as
Antineoplastic AgentsDrug Delivery SystemsEnediynesMagnetite NanoparticlesAnimalsAnthraquinonesCell Line, TumorFemaleFolic AcidHumansMiceStreptomycesAnthraquinonesAntineoplastic AgentsEnediynesFolic AcidMagnetite Nanoparticlesanthraquinone-fused enediynesmagnetic nanoparticlesspecific separationtriple-negative breast cancertumor-targeting
Identifiers
PMID42883295
PMCPMC13666505
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