Targeting Specific Sirtuin Modulation: Emerging Therapeutic Strategies for Healthy Cognitive Ageing and Potential Implications for Alzheimer's Disease.

Charlotte McDermott, Michael H Cole, Madison Pearson, Pia Winberg, Francesca Fernandez

Abstract readReview

In one paragraph

Review in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Charlotte McDermottSchool of Behavioural and Health Sciences, Faculty of Health Sciences, Australian Catholic University, Banyo, QLD 4014, Australia.

Michael H ColeSchool of Behavioural and Health Sciences, Faculty of Health Sciences, Australian Catholic University, Banyo, QLD 4014, Australia.

Madison PearsonSchool of Behavioural and Health Sciences, Faculty of Health Sciences, Australian Catholic University, Banyo, QLD 4014, Australia.ORCID 0000-0002-5092-4610

Pia WinbergSchool of Medical, Indigenous and Health Science, University of Wollongong, Wollongong, NSW 2522, Australia.ORCID 0000-0003-2554-4955

Francesca FernandezSchool of Behavioural and Health Sciences, Faculty of Health Sciences, Australian Catholic University, Banyo, QLD 4014, Australia.ORCID 0000-0002-0926-5473

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nicotinamide adenine dinucleotide (+)-dependent class III histone deacetylases, widely known as sirtuins (SIRTs), have been found to play key functions in a wide range of biological processes implicated in ageing processes. The downregulation of some specific SIRTs was reported in ageing and in some neurological diseases such as Alzheimer's disease. SIRT modulator factors, such as diet, exercise and various natural compounds, have recently emerged as a potential new avenue of therapy to modify the progression of Alzheimer's disease and delay some ageing effects. This review synthesises recent advances in the understanding of the modulatory effects of SIRTs in the context of healthy ageing with a particular focus on cognitive function and implications for Alzheimer's disease.

Indexed as

Alzheimer DiseaseCognitive AgingHealthy AgingSirtuinsAgingAnimalsHumansSirtuinsageingAlzheimer’s diseasecalorie restrictioncognitionexercisenatural compoundsseaweedsirtuin

Identifiers

PMID42883292

DOI10.3390/molecules31193528

PMCPMC13666682

What OpenQuestion holds

Textmetadata

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.