ArticleMolecules (Basel, Switzerland)2026
Anti-Neuroinflammatory Effects of Cardenolides in IL-1β-Activated SK-N-SH Cells.
Lu Sun, Matthias Apweiler, Rami Schulzki, Christoph W Grathwol, Claus Normann, Stefan Bräse, Bernd L Fiebich
Abstract read
In one paragraphArticle in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
7 authors.
Lu SunNeuroimmunology and Neurochemistry Research Group, Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.
Matthias ApweilerNeuroimmunology and Neurochemistry Research Group, Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.
Rami SchulzkiNeuroimmunology and Neurochemistry Research Group, Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.
Christoph W GrathwolInstitute of Biological and Chemical Systems-Functional Molecular Systems (IBCS-FMS), Karlsruhe Institute of Technology (KIT), Kaiserstrasse 12, 76131 Karlsruhe, Germany.ORCID 0000-0003-0232-3279 Claus NormannDepartment of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.
Stefan BräseInstitute of Biological and Chemical Systems-Functional Molecular Systems (IBCS-FMS), Karlsruhe Institute of Technology (KIT), Kaiserstrasse 12, 76131 Karlsruhe, Germany.ORCID 0000-0003-4845-3191 Bernd L FiebichNeuroimmunology and Neurochemistry Research Group, Department of Psychiatry and Psychotherapy, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.ORCID 0000-0002-9261-6771 Funding
Deutsche Forschungsgemeinschaft 266379491Deutsche Forschungsgemeinschaft 284178167Ministerium für Wissenschaft, Forschung und Kunst Baden-Württemberg
6 · The paper itselfAbstract
Neuroinflammation is a key feature of neurological disorders such as Alzheimer's or Parkinson's disease, depression or amyotrophic lateral sclerosis. This study investigates the anti-neuroinflammatory effects of three cardenolide derivatives, digitoxigenin, digitoxigenone, and coroglaucigenin (all at concentrations of 1, 5, 10, and 25 µM), in IL-1β-stimulated human neuroblastoma SK-N-SH cells. All compounds significantly reduced PGE
Indexed as
Anti-Inflammatory AgentsCardenolidesInterleukin-1betaNeuroinflammatory DiseasesCell Line, TumorCell SurvivalCyclooxygenase 2DinoprostoneHumansInterleukin-6NF-kappa Bp38 Mitogen-Activated Protein KinasesProstaglandin-E SynthasesSignal TransductionAnti-Inflammatory AgentsCardenolidesCyclooxygenase 2DinoprostoneInterleukin-1betaInterleukin-6NF-kappa Bp38 Mitogen-Activated Protein KinasesProstaglandin-E SynthasescardenolidescoroglaucigenindigitoxigenindigitoxigenoneIL-1βneuroinflammationSK-N-SH
Identifiers
PMID42883264
PMCPMC13666663
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