ArticleMolecules (Basel, Switzerland)2026
Identification of Imidazole-Benzenesulfonamide Derivatives with Anti-Inflammatory Activity Through Modulation of NF-κB Signaling.
Povilas Kavaliauskas, Valdas Vainauskas, Vidmantas Petraitis, Ruta Petraitiene, Waldo Acevedo, Ramunė Grigalevičiūtė, Birutė Grybaitė, Božena Golcienė, Rolandas Stankevičius, Julius Rakickas and 1 more
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In one paragraphArticle in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
11 authors.
Povilas KavaliauskasInstitute for Genome Sciences, School of Medicine, University of Maryland, 655 W. Baltimore Street, Baltimore, MD 21201, USA.
Valdas VainauskasDepartment of Organic Chemistry, Kaunas University of Technology, Radvilėnų Rd. 19, LT-50254 Kaunas, Lithuania.ORCID 0009-0008-5857-6367 Vidmantas PetraitisInstitute of Infectious Diseases and Pathogenic Microbiology, Birštono Str. 38A, LT-59116 Prienai, Lithuania.ORCID 0000-0001-6811-4467 Ruta PetraitieneInstitute of Infectious Diseases and Pathogenic Microbiology, Birštono Str. 38A, LT-59116 Prienai, Lithuania.ORCID 0000-0002-3269-8058 Waldo AcevedoInstitute of Chemistry, Faculty of Sciences, Pontificia Universidad Católica de Valparaíso, Valparaíso 2373223, Chile.ORCID 0000-0002-1182-0253 Ramunė GrigalevičiūtėBiological Research Center, Lithuanian University of Health Sciences, Tilzes Str. 18/7, LT-47181 Kaunas, Lithuania.
Birutė GrybaitėDepartment of Organic Chemistry, Kaunas University of Technology, Radvilėnų Rd. 19, LT-50254 Kaunas, Lithuania.ORCID 0000-0003-0982-1342 Božena GolcienėDepartment of Organic Chemistry, Kaunas University of Technology, Radvilėnų Rd. 19, LT-50254 Kaunas, Lithuania.
Rolandas StankevičiusDepartment of Animal Nutrition, Lithuanian University of Health Sciences, Tilzes Str. 18, LT-47181 Kaunas, Lithuania.ORCID 0000-0002-8036-9662 Julius RakickasPublic Institution Šilutė Primary Health Care Center, Rusnes Str. 1, LT-99185 Šilutė, Lithuania.
Vytautas MickevičiusDepartment of Organic Chemistry, Kaunas University of Technology, Radvilėnų Rd. 19, LT-50254 Kaunas, Lithuania.ORCID 0000-0002-9961-2941 Funding
Pontifical Catholic University of Valparaíso 044.769/2026
6 · The paper itselfAbstract
Inflammatory disorders remain an important therapeutic challenge, highlighting the need to identify novel small molecules capable of modulating inflammatory signaling. In this study, an in-house library of aromatic and heterocyclic drug-like compounds was screened for inhibition of lipopolysaccharide (LPS)-induced nuclear factor kappa B (NF-κB) activation using THP-1 dual-reporter cells. Eight compounds markedly suppressed NF-κB activity, and five structurally related 4-phenylimidazole-based benzenesulfonamide derivatives (
Indexed as
Anti-Inflammatory AgentsImidazolesNF-kappa BSignal TransductionSulfonamidesAnimalsBenzenesulfonamidesHumansLipopolysaccharidesMacrophagesMiceMolecular Docking Simulationp38 Mitogen-Activated Protein KinasesRAW 264.7 CellsStructure-Activity RelationshipAnti-Inflammatory AgentsBenzenesulfonamidesimidazoleImidazolesLipopolysaccharidesNF-kappa Bp38 Mitogen-Activated Protein KinasesSulfonamidesanti-inflammatory activityimidazole–benzenesulfonamide derivativesNF-κB
Identifiers
PMID42883238
PMCPMC13666921
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