Green Extraction and Molecular Docking-Guided Discovery of Asiaticoside as a Multi-Target Modulator of the SIRT1/HMGB1/p53-p21 Axis in H

Wenkai Li, Jianhua Huang, Fei Zeng, Yuping Wang, Xiong Liu, Junjie Wang, Siyu Liu

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wenkai LiSchool of Pharmacy, Xiangnan University, Chenzhou 423000, China.

Jianhua HuangSchool of Pharmacy, Xiangnan University, Chenzhou 423000, China.ORCID 0009-0004-9918-3114

Fei ZengSchool of Pharmacy, Xiangnan University, Chenzhou 423000, China.ORCID 0000-0002-1555-1812

Yuping WangSchool of Pharmacy, Xiangnan University, Chenzhou 423000, China.

Xiong LiuSchool of Pharmacy, Xiangnan University, Chenzhou 423000, China.

Junjie WangInstitute of Industrial Technology, Xiangnan University, Chenzhou 423000, China.

Siyu LiuSchool of Pharmacy, Xiangnan University, Chenzhou 423000, China.

Funding

Chenzhou Municipal Science and Technology Bureau 2023sfq04Department of Science and Technology of Hunan Province 2023JJ50064Education Department of Hunan Province 22A0589

6 · The paper itself

Abstract

Endothelial cell senescence is a key contributor to vascular ageing and cardiovascular diseases. Asiaticoside, a pentacyclic triterpenoid saponin from

Indexed as

Cellular SenescenceCyclin-Dependent Kinase Inhibitor p21HMGB1 ProteinHydrogen PeroxideSirtuin 1TriterpenesTumor Suppressor Protein p53HumansHuman Umbilical Vein Endothelial CellsMolecular Docking SimulationSignal TransductionasiaticosideCDKN1A protein, humanCyclin-Dependent Kinase Inhibitor p21HMGB1 ProteinHMGB1 protein, humanHydrogen PeroxideSIRT1 protein, humanSirtuin 1TP53 protein, humanTriterpenesTumor Suppressor Protein p53asiaticosideendothelial senescencegreen extractionHMGB1HUVECsmolecular dockingSASPSIRT1

Identifiers

PMID42883216

DOI10.3390/molecules31193451

PMCPMC13666185

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.