Evidence map›Paper›PMID 42883189›Full record

ArticleMolecules (Basel, Switzerland)2026

Distinct Inhibitory Effects of Statin Lactones on Ca

Carlos Cruz-Cortés, Jaroslava Šeflová, L Michel Espinoza-Fonseca

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Carlos Cruz-CortésDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-3781-9664
Jaroslava ŠeflováDepartment of Health and Biomedical Sciences, University of Texas Rio Grande Valley, Brownsville, TX 78521, USA.
L Michel Espinoza-FonsecaDepartment of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0009-0007-1006-6504

Funding

Mechanisms and discovery of small-molecule effectors targeting cardiac ion pumpsR01HL176212 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Lennane Michel Espinoza-Fonseca · 2024 to 2026
$1.7M
National Heart Lung and Blood Institute R01HL176212NHLBI NIH HHS R01 HL176212
6 · The paper itself

Abstract

P-type ATPases share a conserved catalytic architecture but have different sensitivities to small-molecule inhibitors. We previously identified several statins as inhibitors of the sarco/endoplasmic reticulum Ca

Indexed as

Enzyme InhibitorsHydroxymethylglutaryl-CoA Reductase InhibitorsLactonesSarcoplasmic Reticulum Calcium-Transporting ATPasesSodium-Potassium-Exchanging ATPaseAnimalsStructure-Activity RelationshipEnzyme InhibitorsHydroxymethylglutaryl-CoA Reductase InhibitorsLactonesSarcoplasmic Reticulum Calcium-Transporting ATPasesSodium-Potassium-Exchanging ATPaseheterocyclesNa+/K+-ATPaseP-type ATPasesSERCAstatinsstructure–activity relationships

Identifiers

PMID42883189
PMCPMC13665960

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.