Evidence map›Paper›PMID 42883173›Full record

ArticleMolecules (Basel, Switzerland)2026

Quality by Design-Guided Development of

Cristina Ciobanu, Andreea Cornilă, Cobzac Vitalie, Vinicius de Monte Vidal, Victoria Díaz-Tomé, Adriana Trifan, Ioan Tomuță

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Cristina CiobanuDrug Technology Department, Center for Drug Development, Nicolae Testemițanu State University of Medicine and Pharmacy, 2004 Chisinau, Moldova.
Andreea CornilăPharmaceutical Technology and Biopharmacy Department, Iuliu Hațieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.ORCID 0000-0002-3901-0738
Cobzac VitalieThe Laboratory of Tissue Engineering and Cell Cultures, Nicolae Testemitanu State University of Medicine and Pharmacy, 2004 Chisinau, Moldova.ORCID 0000-0002-5010-1163
Vinicius de Monte VidalParaquasil Group, Department of Pharmacology, Pharmacy and Pharmaceutical Technology, Institute of Materials iMATUS, Universidade de Santiago de Compostela (USC), 15706 Santiago de Compostela, Spain.ORCID 0009-0001-8248-4517
Victoria Díaz-ToméParaquasil Group, Department of Pharmacology, Pharmacy and Pharmaceutical Technology, Institute of Materials iMATUS, Universidade de Santiago de Compostela (USC), 15706 Santiago de Compostela, Spain.ORCID 0000-0003-0107-1292
Adriana TrifanDepartment Pharmaceutical Sciences II, Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania.ORCID 0000-0003-2504-2541
Ioan TomuțăPharmaceutical Technology and Biopharmacy Department, Iuliu Hațieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.ORCID 0000-0002-5094-008X

Funding

Agenția Națională pentru Cercetare și Dezvoltare 25.80012.8007.06TC
6 · The paper itself

Abstract

An integrated Quality by Design (QbD) approach was developed for the systematic optimization of

Indexed as

Cynara scolymusLiposomesPlant ExtractsFlavonoidsParticle SizePhenolsFlavonoidsLiposomesPhenolsPlant ExtractsCynara cardunculus var. scolymus L.D-optimal experimental designencapsulation efficiencyliposomeslyophilizationQuality by Designstability

Identifiers

PMID42883173
PMCPMC13666192

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.