Evidence map›Paper›PMID 42883166›Full record

ReviewMolecules (Basel, Switzerland)2026

New Insights into the Pharmacological Effects and Potential Health Benefits of Volatile Phenylpropenes.

Simona-Codruța Hegheș, Oliviu Vostinaru, Anamaria Apan, Cristina Pop, Irina Iaru, Cristina Mogoșan, Mozaniel Santana de Oliveira, Oana Mîrza, Lorena Filip

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Simona-Codruța HegheșDepartment of Drug Analysis, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania.ORCID 0000-0001-7823-4390
Oliviu VostinaruDepartment of Pharmacology, Physiology and Physiopathology, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania.ORCID 0000-0003-4505-4005
Anamaria ApanDepartment of Pharmacology, Physiology and Physiopathology, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania.ORCID 0000-0002-3749-7589
Cristina PopDepartment of Pharmacology, Physiology and Physiopathology, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania.ORCID 0000-0002-9088-8589
Irina IaruDepartment of Pharmacology, Physiology and Physiopathology, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania.
Cristina MogoșanDepartment of Pharmacology, Physiology and Physiopathology, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania.ORCID 0000-0002-6854-2194
Mozaniel Santana de OliveiraLaboratory of Pharmacology of Inflammation and Behavior, Federal University of Para, Belem 66075-900, PA, Brazil.ORCID 0000-0002-4076-2443
Oana MîrzaDepartment of Bromatology, Hygiene, Nutrition, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania.ORCID 0000-0003-3771-9003
Lorena FilipDepartment of Bromatology, Hygiene, Nutrition, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania.ORCID 0000-0001-9469-3546

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phenylpropenes are a significant category of plant volatile compounds that play a crucial role in enhancing the flavor of a variety of herbs and spices. They are a subclass of phenylpropanoid compounds, being important constituents in several plant species like basil, clove, cinnamon, anise, sassafras, nutmeg, and fennel. The most common molecules from the phenylpropene group are represented by anethole, chavicol, cinnamaldehyde, estragole, eugenol, myristicin (methoxy-safrole), and safrole. Beyond their culinary and cosmetic applications, phenylpropenes have been found to have multiple pharmacological effects, including being antimicrobial, antitumoral, antioxidant, anti-inflammatory, antidiabetic, and hypolipemic. This review is focused on the presentation of the latest scientific data resulting mainly from preclinical in vivo and in vitro studies which investigated the pharmacological effects of phenylpropenes, highlighting also the potential health benefits of phenylpropenes in several infectious, inflammatory, cardiovascular, and metabolic diseases. Mechanistic aspects regarding their biological effects and additional safety data are also reviewed.

Indexed as

Volatile Organic CompoundsAcroleinAllylbenzene DerivativesAnimalsAnisolesAnti-Infective AgentsAnti-Inflammatory AgentsAntioxidantsDioxolanesEugenolHumansHypoglycemic AgentsPyrogallolSafroleAcroleinAllylbenzene DerivativesanetholeAnisolesAnti-Infective AgentsAnti-Inflammatory AgentsAntioxidantscinnamaldehydeDioxolanesEugenolHypoglycemic AgentsmyristicinPyrogallolSafroleVolatile Organic Compoundsanti-biofilmantidiabeticanti-inflammatoryantimicrobialantitumoralphenylpropenes

Identifiers

PMID42883166
PMCPMC13666226

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.