ArticleMolecules (Basel, Switzerland)2026
Hikaru Fukuda, Yukina Sanada, Satoshi Fujii, Kazuhisa Fujimoto, Masaki Morishita, Naomi Yada, Osamu Takahashi, Manabu Habu, Shigeori Takenaka, Hiroshi Takeuchi and 1 more
Abstract read
In one paragraphArticle in Molecules (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
11 authors.
Hikaru FukudaDepartment of Science of Physical Functions, Division of Maxillofacial Surgery, Kyushu Dental University, 2-6-1 Manazuru, Kokurakita-ku, Kitakyushu 803-8580, Fukuoka, Japan.ORCID 0009-0005-4811-0051 Yukina SanadaDepartment of Applied Chemistry, Kyushu Institute of Technology, 1-1 Sensui-cho, Tobata-ku, Kitakyushu 804-8550, Fukuoka, Japan.
Satoshi FujiiDepartment of Bioscience and Bioinformatics, Kyushu Institute of Technology, 680-4 Kawazu, Iizuka 820-8502, Fukuoka, Japan.
Kazuhisa FujimotoDepartment of Applied Chemistry and Biochemistry, Kyushu Sangyo University, 2-3-1 Matsukadai, Higashi-ku, Fukuoka 813-8503, Fukuoka, Japan.
Masaki MorishitaDepartment of Comprehensive Dental Practice Education Development, Kyushu Dental University, 2-6-1 Manazuru, Kokurakita-ku, Kitakyushu 803-8580, Fukuoka, Japan.ORCID 0000-0002-6335-5947 Naomi YadaDepartment of Health Promotion, Division of Oral Pathology, Kyushu Dental University, 2-6-1 Manazuru, Kokurakita-ku, Kitakyushu 803-8580, Fukuoka, Japan.ORCID 0000-0001-7267-6040 Osamu TakahashiDepartment of Science of Physical Functions, Division of Maxillofacial Surgery, Kyushu Dental University, 2-6-1 Manazuru, Kokurakita-ku, Kitakyushu 803-8580, Fukuoka, Japan.ORCID 0000-0002-0564-2462 Manabu HabuDepartment of Science of Physical Functions, Division of Maxillofacial Surgery, Kyushu Dental University, 2-6-1 Manazuru, Kokurakita-ku, Kitakyushu 803-8580, Fukuoka, Japan.ORCID 0000-0002-6586-2539 Shigeori TakenakaDepartment of Applied Chemistry, Kyushu Institute of Technology, 1-1 Sensui-cho, Tobata-ku, Kitakyushu 804-8550, Fukuoka, Japan.
Hiroshi TakeuchiDepartment of Health Promotion, Division of Applied Pharmacology, Kyushu Dental University, 2-6-1 Manazuru, Kokurakita-ku, Kitakyushu 803-8580, Fukuoka, Japan.ORCID 0000-0003-0033-2913 Shinobu SatoDepartment of Applied Chemistry, Kyushu Institute of Technology, 1-1 Sensui-cho, Tobata-ku, Kitakyushu 804-8550, Fukuoka, Japan.ORCID 0000-0002-3813-0535 Funding
Fukuoka Public Health Promotion Organization Cancer Research Fund
6 · The paper itselfAbstract
G-quadruplexes (G4s) have attracted considerable attention as molecular targets for the development of anticancer agents with improved selectivity and safety profiles. Cyclic anthraquinone derivatives have been developed as G4-binding ligands, and our previous studies demonstrated that cAQ-mBen preferentially binds to nuclear G4 structures, including telomeric and c-MYC G4s, and exhibits potent anticancer activity. In the present study, we examined the interaction of cAQ-mBen with the mitochondrial G4-forming oligonucleotide mt6363 and performed an exploratory single-dose tolerability assessment in rats. UV-visible absorption titration using the mitochondrial G4-forming sequence mt6363 revealed an association constant (
Indexed as
AnthraquinonesAntineoplastic AgentsDNA, MitochondrialG-QuadruplexesMitochondriaAnimalsCircular DichroismMaleRatsAnthraquinonesAntineoplastic AgentsDNA, Mitochondrialacute tolerabilitycAQ-mBencyclic anthraquinoneG-quadruplexmitochondrial DNAMT-ND3
Identifiers
PMID42883163
PMCPMC13666387
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