Evidence map›Paper›PMID 42883082›Full record

ArticleAnimals : an open access journal from MDPI2026

Longitudinal Changes in Testicular Volume and the Additional Value of Body Weight for Estimating Histology-Linked Testicular Development in Male Cynomolgus Macaques (

Ryosuke Kawashima, Hirofumi Matsumoto, Atsushi Asano

Abstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ryosuke KawashimaDrug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd., Kagoshima 891-1394, Japan.
Hirofumi MatsumotoDrug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd., Kagoshima 891-1394, Japan.
Atsushi AsanoJoint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima 890-0065, Japan.ORCID 0000-0002-3965-615X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Individual variation in pubertal development limits the usefulness of chronological age alone for assessing testicular development in male cynomolgus macaques. This retrospective study characterized longitudinal changes in externally measured testicular volume and evaluated the additional information provided by body weight in Chinese- and Cambodian-origin animals. Routine records collected between 2006 and 2026 were analyzed. After data cleaning, 31,310 observations from 22,305 animals were available, including 4331 animals with repeated measurements. A prespecified mean bilateral testicular volume threshold of 8.68 cm

Indexed as

animal selectionbody weightcynomolgus macaquegeographic originlongitudinal analysisMacaca fascicularisnonclinical safety studypubertal developmentreproductive toxicologytesticular volume

Identifiers

PMID42883082
PMCPMC13663561

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.