Evidence map›Paper›PMID 42883069›Full record

ArticleAnimals : an open access journal from MDPI2026

Untargeted Metabolomic Profiling of Spermatozoa and Seminal Plasma Identifies Candidate Metabolic Indicators of Semen Quality in Holstein Bulls.

Olga Kostyunina, Alexey Traspov, Anton Ermilov, Faridun Bakoev, Gleb Nemkovskiy, Alexander Kusnetzov, Vladimir Belyakov

Abstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Olga KostyuninaLLC «WESTTRADE Ltd.», 115201 Moscow, Russia.ORCID 0000-0001-8206-3221
Alexey TraspovLLC «WESTTRADE Ltd.», 115201 Moscow, Russia.ORCID 0000-0003-1618-2577
Anton ErmilovLLC «WESTTRADE Ltd.», 115201 Moscow, Russia.
Faridun BakoevLLC «WESTTRADE Ltd.», 115201 Moscow, Russia.
Gleb NemkovskiyLLC «WESTTRADE Ltd.», 115201 Moscow, Russia.ORCID 0000-0003-1897-1975
Alexander KusnetzovLLC «WESTTRADE Ltd.», 115201 Moscow, Russia.
Vladimir BelyakovLLC «WESTTRADE Ltd.», 115201 Moscow, Russia.

Funding

Russian Science Foundation 24-16-00198
6 · The paper itself

Abstract

This exploratory study applied untargeted LC-MS/MS metabolomic profiling to investigate metabolic differences between Holstein bulls with high-quality (HQ) and low-quality (LQ) semen in both spermatozoa and seminal plasma. Bulls were classified based on long-term routine semen quality records and ejaculate rejection rates, providing a stable and biologically meaningful grouping. A total of 249 unique metabolites were annotated across both biological matrices. Differential analysis identified 46 LC-MS features corresponding to 44 unique metabolites in spermatozoa and 11 LC-MS features corresponding to 9 unique metabolites in seminal plasma that met the predefined multi-criteria selection thresholds (FDR < 0.05, |log

Indexed as

amino acid metabolismHolstein bullsLC–MS/MSmetabolomic profilingmetabolomicssemen qualityseminal plasmaspermatozoa

Identifiers

PMID42883069
PMCPMC13663586

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.