ArticleAnimals : an open access journal from MDPI2026
Oral Mosapride Attenuates Gastrointestinal Dysmotility During Experimental Endotoxemia in Horses: A Randomized, Blinded Crossover Study.
Diego Duarte Varela, Ana Carolina Ribeiro Rosa, Lara Nunes Sousa, Eduarda Zancanaro Luvison, Ana Moutinho Vilella Machado, Marcella Procópio Valle Couto, Dietrich Pizzigatti, Luiz Eduardo Duarte de Oliveira, Fabíola de Oliveira Paes Leme, Livia Camargo Garbin and 3 more
Abstract read
In one paragraphArticle in Animals : an open access journal from MDPI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
13 authors.
Diego Duarte VarelaEQUINOVA Research Group, Department of Veterinary Medicine and Surgery, Veterinary School, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, Brazil.ORCID 0009-0004-8141-5706 Ana Carolina Ribeiro RosaEQUINOVA Research Group, Department of Veterinary Medicine and Surgery, Veterinary School, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, Brazil.ORCID 0009-0002-6204-2751 Lara Nunes SousaEQUINOVA Research Group, Department of Veterinary Medicine and Surgery, Veterinary School, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, Brazil.ORCID 0000-0001-7737-5714 Eduarda Zancanaro LuvisonEQUINOVA Research Group, Department of Veterinary Medicine and Surgery, Veterinary School, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, Brazil.
Ana Moutinho Vilella MachadoEQUINOVA Research Group, Department of Veterinary Medicine and Surgery, Veterinary School, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, Brazil.ORCID 0009-0006-9504-3020 Marcella Procópio Valle CoutoVeterinary School, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, Brazil.ORCID 0009-0002-5036-1595 Dietrich PizzigattiEquine Development Pole, Northeast Regional University Center (CENUR-Noreste) of the University of the Republic (UdelaR), Melo 37000, Uruguay.ORCID 0000-0002-2862-8743 Luiz Eduardo Duarte de OliveiraVeterinary School, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, Brazil.
Fabíola de Oliveira Paes LemeVeterinary School, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, Brazil.
Livia Camargo GarbinEQUINOVA Research Group, Department of Veterinary Medicine and Surgery, Veterinary School, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, Brazil.
Heloísa de Paula PedrozaVeterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University (LSU), Baton Rouge, LA 70803, USA.ORCID 0000-0002-2560-3081 Rafael Resende FaleirosEQUINOVA Research Group, Department of Veterinary Medicine and Surgery, Veterinary School, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, Brazil.ORCID 0000-0003-2747-5535 Armando Mattos CarvalhoEQUINOVA Research Group, Department of Veterinary Medicine and Surgery, Veterinary School, Federal University of Minas Gerais (UFMG), Belo Horizonte 31270-901, Brazil.ORCID 0000-0003-3007-1144 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Endotoxemia is a major contributor to gastrointestinal hypomotility and postoperative ileus in horses. This study investigated whether oral mosapride retained prokinetic activity during acute lipopolysaccharide (LPS)-induced endotoxemia. Seven healthy adult horses were enrolled in a randomized, blinded, three-period crossover trial and received LPS alone, mosapride alone (MOSA), or LPS plus mosapride (LPS + MOSA), with a 14-day washout interval between periods. Mosapride was administered orally at 2 mg/kg, whereas endotoxemia was induced by an intravenous infusion of
Indexed as
5-HT4 receptorequinehypomotilitylipopolysaccharidepostoperative ileusprokinetic
Identifiers
PMID42883002
PMCPMC13663327
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