Integrated Multi-Omics Analysis Identifies Potential Associations of Unfermented and Fermented Astragalus Straw with Serum Antioxidant Status and Lipid Metabolism in Lambs.

Shulin Liu, Kun Yang, Ruifeng Yang, Huan Shi, Zhixiang Zhao, Yuanyuan Xing

Abstract read

In one paragraph

Article in Animals : an open access journal from MDPI, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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6 authors.

Shulin LiuDepartment of Agriculture, Animal Husbandry and Food Science, Hetao College, Bayannur 015000, China.

Kun YangCollege of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China.

Ruifeng YangDepartment of Mechanical and Electrical Engineering, Hetao College, Bayannur 015000, China.

Huan ShiDepartment of Agriculture, Animal Husbandry and Food Science, Hetao College, Bayannur 015000, China.

Zhixiang ZhaoDepartment of Mechanical and Electrical Engineering, Hetao College, Bayannur 015000, China.

Yuanyuan XingCollege of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigated the effects of fermented and unfermented Astragalus straw on serum antioxidant status, lipid metabolism, and hormone profiles in lambs and explored the underlying mechanisms using 16S rRNA sequencing and untargeted metabolomics. Twenty-seven weaned lambs were randomly assigned to three groups: a control group fed a basal total mixed ration (CON), an unfermented Astragalus straw supplementation group (AM_S), and a fermented Astragalus straw supplementation group (FAM_S). The experiment consisted of a 15-day adaptation period followed by a 90-day feeding period. At the end of the trial, growth performance was evaluated and serum samples were collected. Six lambs from each group were randomly selected and euthanized for the collection of rumen fluid and liver tissues for omics analyses. Compared with the CON group, both the AM_S and FAM_S groups showed significantly improved growth performance (

Indexed as

antioxidantAstragalus strawlambsmetabolomics

Identifiers

PMID42882970

DOI10.3390/ani16193001

PMCPMC13663450

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.