ArticleCancers2026
Worsening of Oral Health Parameters After Head and Neck Radiotherapy-Findings from a Multidisciplinary Head and Neck Tumor Board: A Prospective Observational Study.
Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04009161 (Osteoradionecrosis Rate in Patients Undergoing Radiotherapy for Head and Neck Cancer Treatment), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Osteoradionecrosis Rate in Patients Undergoing Radiotherapy for Head and Neck Cancer Treatment: a Perspective Clinical Study.
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate (a) changes in caries experience, (b) changes in periodontal status, and (c) the need for dental extractions in a cohort of patients treated with radiotherapy (RT) and chemoradiotherapy (RTCT) for head and neck cancer (HNC).
methodsThis prospective cohort study was approved by the local Ethics Committee (Ref. 22858/18) and registered at ClinicalTrials.gov (ID: NCT04009161). The study population consisted of patients with HNC who, prior to RT, underwent a dental examination followed by the elimination of oral foci of infection and were then enrolled in a follow-up program. The primary outcome was oral health worsening, defined as the onset of severe periodontitis and/or a DMFt score ≥ 13. Oral cavity RT dose was obtained contouring the 'buccal mucosa' organ at risk (OAR).
resultsIn total, 113 patients were included (median follow-up: 44.77 months). The sample mainly included oral, oropharyngeal, nasopharyngeal and laryngeal cancers (89/113, 78.8%). Salivary glands, hypopharynx and other sites accounted for a minority of the cases (24/113, 21.2%). Seventeen patients (34.7%) experienced worsening of oral health status over time, which was associated with smoking (OR = 4.7, 95% CI: 1.27-17.37;
conclusionsPatients treated with RT experienced significant deterioration in dental and periodontal health, and oral cavity dosimetric parameters might be associated with tooth loss, although this association requires confirmation in further studies.
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