Evidence map›Paper›PMID 42882886›Full record

ReviewCancers2026

Sleep Impairment in Oncology: Development of a Novel Patient-Centric Conceptual Model.

Harriet Makin, Sophie Van Tomme, Natalie V J Aldhouse, Samantha Wratten, Helen Kitchen, Chloe Carmichael, Cecile Gousset, Paul Cordero

Abstract readReview
In one paragraph

Review in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Harriet MakinClinical Outcomes Assessment, Clarivate Analytics, 70. St Mary Axe, London EC3A 8BE, UK.ORCID 0000-0002-1769-2205
Sophie Van TommePatient-Driven Medicines Development, Sanofi, Paasheuvelweg 25, 1105BP Amsterdam, The Netherlands.ORCID 0009-0001-4737-0987
Natalie V J AldhouseClinical Outcomes Assessment, Clarivate Analytics, 70. St Mary Axe, London EC3A 8BE, UK.ORCID 0000-0001-6573-7431
Samantha WrattenClinical Outcomes Assessment, Clarivate Analytics, 70. St Mary Axe, London EC3A 8BE, UK.ORCID 0000-0003-0552-181X
Helen KitchenClinical Outcomes Assessment, Clarivate Analytics, 70. St Mary Axe, London EC3A 8BE, UK.ORCID 0000-0001-5519-0794
Chloe CarmichaelClinical Outcomes Assessment, Clarivate Analytics, 70. St Mary Axe, London EC3A 8BE, UK.ORCID 0000-0002-2278-2176
Cecile GoussetPatient-Driven Medicines Development, Sanofi, 82 Avenue Raspail, 94255 Gentilly, France.ORCID 0009-0004-8820-8822
Paul CorderoPatient-Driven Medicines Development, Sanofi, 410 Thames Valley Park Dr, Earley, Reading RG6 1PT, UK.

Funding

Sanofi
6 · The paper itself

Abstract

BACKGROUND/

objectivesUp to 95% of cancer patients report sleep disturbances or disorders. These can potentially influence cancer development and outcomes. This study aimed to review the existing literature to understand the patient experience of cancer-related sleep impairment across indications and treatments, to improve awareness and inform disease treatment/management.

methodsA targeted literature review of published qualitative studies exploring sleep impairment in oncology was conducted in MEDLINE, Embase, and PsycINFO. Concepts were extracted from the reviewed articles, and patient quotes or author descriptions/interpretations were subject to secondary analysis using semantic, qualitative, directed content analysis techniques via ATLAS.ti. Results informed the development of a patient-centric conceptual model.

resultsFrom 482 identified publications, 22 publications were selected for in-depth review and concept extraction, collectively including 531 patients across 25 different oncology indications. Cancer-related sleep impairment frequently affected patients living with cancer, who reported difficulty obtaining good quality sleep, including difficulty falling asleep and staying asleep. Sleep problems were triggered by the emotional anxiety of life with cancer, cancer-related symptoms, treatments and side effects, and external factors. Poor sleep greatly impacted daily life for patients, with difficulties in daily life causing further sleep impairment, in a cyclical relationship.

conclusionsThis study determined that there is an unmet need for treatment of sleep impairment in oncology to improve patient outcomes. The holistic conceptual model developed in this study can provide an important basis for selecting, developing, or modifying outcome measures to assess relevant sleep outcomes, facilitating discussion between patients and clinicians and improving disease treatment/management.

Indexed as

cancercancer-related sleep impairmentconceptual modelhealth-related quality of lifepatient experiencequalitative researchsleep

Identifiers

PMID42882886
PMCPMC13664054

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.