Evidence map›Paper›PMID 42882874›Full record

ArticleCancers2026

Nasopharyngeal Angiofibroma in Adults: Age-Stratified Stage Distribution, Clinical Outcomes, and Exploratory Tumor-Normal Genomics.

Haoyuan Xu, Huankang Zhang, Wanpeng Li, Shixing Zheng, Xiaole Song, Jingjing Wang, Quan Liu, Dehui Wang, Zhuofu Liu

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In one paragraph

Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Haoyuan XuDepartment of Otolaryngology-Head and Neck Surgery, Eye & ENT Hospital of Fudan University, 83 Fenyang Road, Shanghai 200031, China.
Huankang ZhangDepartment of Otolaryngology-Head and Neck Surgery, Eye & ENT Hospital of Fudan University, 83 Fenyang Road, Shanghai 200031, China.
Wanpeng LiDepartment of Otolaryngology-Head and Neck Surgery, Eye & ENT Hospital of Fudan University, 83 Fenyang Road, Shanghai 200031, China.
Shixing ZhengDepartment of Otolaryngology-Head and Neck Surgery, Eye & ENT Hospital of Fudan University, 83 Fenyang Road, Shanghai 200031, China.ORCID 0000-0001-8207-3657
Xiaole SongDepartment of Otolaryngology-Head and Neck Surgery, Eye & ENT Hospital of Fudan University, 83 Fenyang Road, Shanghai 200031, China.
Jingjing WangDepartment of Otolaryngology-Head and Neck Surgery, Eye & ENT Hospital of Fudan University, 83 Fenyang Road, Shanghai 200031, China.
Quan LiuDepartment of Otolaryngology-Head and Neck Surgery, Eye & ENT Hospital of Fudan University, 83 Fenyang Road, Shanghai 200031, China.
Dehui WangDepartment of Otolaryngology-Head and Neck Surgery, Eye & ENT Hospital of Fudan University, 83 Fenyang Road, Shanghai 200031, China.
Zhuofu LiuDepartment of Otolaryngology-Head and Neck Surgery, Eye & ENT Hospital of Fudan University, 83 Fenyang Road, Shanghai 200031, China.ORCID 0000-0001-9139-6327

Funding

Science and Technology Commission of Shanghai Municipality 23YF1404600Science and Technology Commission of Shanghai Municipality 24SF1904700Shanghai Hospital Development Center SHDC12018118
6 · The paper itself

Abstract

BACKGROUND/

objectivesNasopharyngeal angiofibroma (NA) is generally benign, but recurrent disease and rare malignant transformation remain clinically relevant beyond adolescence. We examined adult clinical presentations, records of malignant transformation, and age-related differences in stage distribution.

methodsWe retrospectively reviewed 289 surgically treated patients from January 2006 through June 2026. Radkowski stage distributions were compared between patients aged > 30 and ≤30 years using exact tests. Detailed clinical records were reviewed for 16 adults, and whole-genome sequencing (WGS) annotation summaries were examined for one tumor-blood pair.

resultsTwenty-five patients (8.7%) were older than 30 years; stage was available for 287 patients. In the detailed adult subgroup, a prior pathology-slide record described focal malignant transformation with a Ki-67 index of approximately 50% in one recurrent tumor. Two other patients had database transformation entries without accompanying pathological documentation. Four recurrences and three deaths were recorded, all in stage IIIB disease. Three men had colorectal or rectal cancer histories. Low-, intermediate-, and advanced-stage tumors accounted for 36.0%, 36.0%, and 28.0% of adult cases, compared with 17.6%, 57.3%, and 25.2% of younger cases (

conclusionsAdult NA included recurrent stage IIIB disease and a documented record of focal malignant transformation. Stage distributions differed between age groups. These clinical observations support pathological reassessment of recurrent tumors. The single-case genomic findings remain descriptive annotations.

Indexed as

adultclinical phenotypenasopharyngeal angiofibromaRadkowski stagerecurrencewhole-genome sequencing

Identifiers

PMID42882874
PMCPMC13664208

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.