ReviewCancers2026
Pancreatic Cancer-Associated Pain Management Beyond Opioids: Integrating Oncological Treatment, Palliative Care, and Interventional Pain Medicine.
Review in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pain is one of the most frequent and burdensome symptoms of pancreatic cancer and may substantially impair quality of life throughout the disease trajectory. Its complex and evolving etiology, involving visceral, neuropathic, somatic, and treatment-related mechanisms, frequently makes adequate pain control challenging. This critical narrative review provides a multidisciplinary overview of pancreatic cancer-associated pain management, integrating oncological treatment, palliative and pharmacological care, and interventional pain management into a practical clinical framework. Anticancer therapies, including chemotherapy and radiotherapy, may provide clinically meaningful analgesia in addition to their disease-controlling effect. Early integration of palliative care enables repeated symptom assessment, individualized pharmacological treatment, and management of the psychological, social, and spiritual dimensions of total pain. When conventional analgesic strategies provide insufficient relief or cause intolerable adverse effects, interventional techniques such as coeliac plexus neurolysis, splanchnic neurolysis, or intrathecal drug delivery can complement ongoing oncological and palliative treatment. Rather than following a rigid stepwise analgesic approach, pancreatic cancer-associated pain management should be individualized according to pain mechanism, disease stage and anatomy, previous treatments, functional status, expected survival, and patient preferences. Based on the available evidence and multidisciplinary clinical considerations, we propose a practical patient-centered pathway that dynamically integrates disease-directed, pharmacological, supportive, and interventional strategies throughout the disease course. Early multidisciplinary collaboration and continuous reassessment may facilitate timely treatment escalation and improve pain control while minimizing treatment burden.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.