ArticleCancers2026
Outcomes and Prognostic Factors of Salvage Surgery for Recurrent Oral Squamous Cell Carcinoma.
Article in Cancers, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
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Abstract
backgroundRecurrent oral squamous cell carcinoma (rOSCC) is associated with a poor prognosis, and evidence supporting risk stratification in the salvage setting remains limited. The prognostic value of conventional staging systems and tumor-related characteristics after recurrence has not yet been fully established.
methodsWe conducted a single-center observational study including patients with rOSCC who had previously undergone treatment for pT1-2 N0M0 OSCC, all subsequently surgically salvaged. Clinical, histopathological, and recurrence-related variables were collected. Recurrent tumors were classified according to the AJCC TNM staging system, the Composite Oral Cavity and Oropharynx Recurrence Staging System (CORSS), and the Same-Up-Down staging system (SUDss), a novel staging system developed by our group.
resultsA total of 49 patients were included. Several pathological characteristics, including the rT3-4 category (
conclusionsCORSS appears to offer complementary prognostic value compared with conventional rTNM in patients with surgically treated rOSCC, although formal comparative validation of discrimination and calibration is warranted. Pathological lymph node involvement and close or positive surgical margins were the most relevant independent adverse prognostic factors. These findings identify higher-risk patients but do not, by themselves, establish a benefit from treatment intensification.
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