Evidence map›Paper›PMID 42882621›Full record

ReviewMaterials (Basel, Switzerland)2026

Zinc Oxide Nanoparticles as Drug Delivery Tools.

Amir Nasrolahi Shirazi, Rajesh Vadlapatla, Ajoy Koomer, Kimberly Tang, Keykavous Parang

Abstract readReview
In one paragraph

Review in Materials (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Amir Nasrolahi ShiraziDepartment of Pharmaceutical Sciences, College of Pharmacy, Marshall B. Ketchum University, 2575 Yorba Linda Blvd., Fullerton, CA 92831, USA.
Rajesh VadlapatlaDepartment of Pharmaceutical Sciences, College of Pharmacy, Marshall B. Ketchum University, 2575 Yorba Linda Blvd., Fullerton, CA 92831, USA.ORCID 0000-0003-0519-2198
Ajoy KoomerDepartment of Pharmaceutical Sciences, College of Pharmacy, Marshall B. Ketchum University, 2575 Yorba Linda Blvd., Fullerton, CA 92831, USA.
Kimberly TangDepartment of Pharmaceutical Sciences, College of Pharmacy, Marshall B. Ketchum University, 2575 Yorba Linda Blvd., Fullerton, CA 92831, USA.
Keykavous ParangCenter for Targeted Drug Delivery, Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Harry and Diane Rinker Health Science Campus, 9401 Jeronimo Rd, Irvine, CA 92618, USA.ORCID 0000-0001-8600-0893

Funding

Peptide-Doxorubicin Conjugates for Mitigating Cardiotoxicity and Overcoming Drug Resistance in CancerR15CA301437 · NCI · CHAPMAN UNIVERSITY · PI PARANG, KEYKAVOUS, YANG, SUN · 2025 to 2025
$416k
NCI NIH HHS R15 CA301437NIH HHS 1R15CA301437-01
6 · The paper itself

Abstract

Zinc oxide nanoparticles (ZnO-NPs) have emerged as promising inorganic nanocarriers for drug delivery due to their unique physicochemical properties, pH-responsive biodegradability, high surface area, and intrinsic biological activity. Their dissolution under acidic conditions enables controlled drug release within the tumor microenvironment and intracellular compartments, improving therapeutic selectivity while aiming to reduce off-target exposure. Surface functionalization with polyethylene glycol (PEG), chitosan, hyaluronic acid, and folic acid has further improved nanoparticle stability, prolonged circulation, and promoted receptor-mediated cellular uptake in targeted tissues. Beyond serving as drug carriers, ZnO-NPs exhibit intrinsic anticancer, antimicrobial, and anti-inflammatory activities, primarily through the generation of reactive oxygen species and controlled release of Zn

Indexed as

drug deliverymetal nanoparticlesZinc oxide nanoparticles

Identifiers

PMID42882621
PMCPMC13666354

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.